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Molecular and Clinical Oncology
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Article

Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma

  • Authors:
    • Yu Chen
    • Song‑Feng Xu
    • Ming Xu
    • Xiu‑Chun Yu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, General Hospital of Jinan Military Command Region, Jinan, Shandong 250031, P.R. China
  • Pages: 495-500
    |
    Published online on: March 9, 2015
       https://doi.org/10.3892/mco.2015.528
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Abstract

There is controversy regarding the impact of infection on long‑term prognosis in osteosarcoma patients. Clinical trials and experiments relating to this field could bring reconsideration of immunotherapy for osteosarcoma. The clinical records were reviewed of 125 osteosarcoma patients with a mean follow‑up of 5.1±3.9 years (range, 0.5‑19.8 years), and a review of the literature was also carried out. Chronic localized infections (but not systemic infection) were determined in 6 patients (4.8%). Similar chemotherapeutic regimens (P=1.00) and histological reactions (P=0.65) were observed in patients with or without infection. Tumor location of proximal tibia (P=0.04) was more common in infected patients. More amputations (P<0.001) were necessitated in infected patients due to uncontrolled infection. The 5‑year overall survival rate and event‑free survival rate in infected patients were 100%, which were significantly higher than that of the non‑infected patients, of whom the rates were 54 and 43% respectively (log‑rank test: total survival, P=0.01; tumor‑free survival, P=0.01). Distant metastasis was an independent risk factor for survival determined by Cox regression analysis (P<0.001, 95 confidence interval, 1.59‑3.98). These findings suggested infection was likely to have positive effects on survival in osteosarcoma patients, however, underlying mechanisms remain to be elucidated. Reconsideration of the association of infection and survival in osteosarcoma patients will help to explore novel therapeutic routes and targets in these patients.
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1 

Agarwal M, Anchan C, Shah M, Puri A and Pai S: Limb salvage surgery for osteosarcoma: Effective low-cost treatment. Clin Orthop Relat Res. 459:82–91. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Lee JA, Kim MS, Kim DH, Lim JS, Park KD, Cho WH, Song WS, Lee SY and Jeon DG: Postoperative infection and survival in osteosarcoma patients. Ann Surg Oncol. 16:147–151. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Li X, Moretti VM, Ashana AO and Lackman RD: Perioperative infection rate in patients with osteosarcomas treated with resection and prosthetic reconstruction. Clin Orthop Relat Res. 469:2889–2894. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Shin DS, Weber KL, Chao EY, An KN and Sim FH: Reoperation for failed prosthetic replacement used for limb salvage. Clin Orthop Relat Res. 358:53–63. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Gorelick MH, Owen WC, Seibel NL and Reaman GH: Lack of association between neutropenia and the incidence of bacteremia associated with indwelling central venous catheters in febrile pediatric cancer patients. Pediatr Infect Dis J. 10:506–510. 1991. View Article : Google Scholar : PubMed/NCBI

6 

Hingorani P, Seidel K, Krailo M, Mascarenhas L, Meyers P, Marina N, Conrad EU and Hawkins DS: Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: A report from the Children's Oncology Group. Pediatr Blood Cancer. 57:939–942. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wirganowicz PZ, Eckardt JJ, Dorey FJ, Eilber FR and Kabo JM: Etiology and results of tumor endoprosthesis revision surgery in 64 patients. Clin Orthop Relat Res. 358:64–74. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Pan KL, Chan WH, Ong GB, Premsenthil S, Zulkarnaen M, Norlida D and Abidin Z: Limb salvage in osteosarcoma using autoclaved tumor-bearing bone. World J Surg Oncol. 10:1052012. View Article : Google Scholar : PubMed/NCBI

9 

Jeys LM, Grimer RJ, Carter SR, Tillman RM and Abudu A: Post operative infection and increased survival in osteosarcoma patients: Are they associated? Ann Surg Oncol. 14:2887–2895. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Lascelles BD, Dernell WS, Correa MT, Lafferty M, Devitt CM, Kuntz CA, Straw RC and Withrow SJ: Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma. Ann Surg Oncol. 12:1073–1083. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Sottnik JL, U'Ren LW, Thamm DH, Withrow SJ and Dow SW: Chronic bacterial osteomyelitis suppression of tumor growth requires innate immune responses. Cancer Immunol Immunother. 59:367–378. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Noor S, Thornormoethsson HS, Zervas CT, et al: Limb versus life-the outcomes of osteosarcoma in Cambodia. Int Orthop. 38:579–585. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ando K, Heymann MF, Stresing V, Mori K, Rédini F and Heymann D: Current therapeutic strategies and novel approaches in osteosarcoma. Cancers (Basel). 5:591–616. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Jeon DG, Song WS, Kong CB, Cho WH, Cho SH, Lee JD and Lee SY: Role of surgical margin on local recurrence in high risk extremity osteosarcoma: A case-controlled study. Clin Orthop Surg. 5:216–224. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Prokuski L: Prophylactic antibiotics in orthopaedic surgery. J Am Acad Orthop Surg. 16:283–293. 2008.PubMed/NCBI

18 

Wiemann B and Starnes CO: Coley's toxins, tumor necrosis factor and cancer research: A historical perspective. Pharmacol Ther. 64:529–564. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Werneke U: A guide to using complementary alternative medicines in cancer. Nurs Times. 101:32–35. 2005.PubMed/NCBI

20 

Buddingh EP, Schilham MW, Ruslan SE, Berghuis D, Szuhai K, Suurmond J, Taminiau AH, Gelderblom H, Egeler RM, Serra M, et al: Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells. Cancer Immunol Immunother. 60:575–586. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Thomas-Tikhonenko A and Hunter CA: Infection and cancer: The common vein. Cytokine Growth Factor Rev. 14:67–77. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Buddingh EP, Ruslan SE, Berghuis D, Gelderblom H, Anninga JK, Hogendoorn PC, Egeler RM, Schilham MW and Lankester AC: Intact interferon signaling in peripheral blood leukocytes of high-grade osteosarcoma patients. Cancer Immunol Immunother. 61:941–947. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Whelan JS, Bielack SS, Marina N, et al: EURAMOS-1, an international randomised study for osteosarcoma: Results from pre-randomisation treatment. Ann Oncol. 26:407–414. 2015. View Article : Google Scholar : PubMed/NCBI

24 

De Palma M, Mazzieri R, Politi LS, Pucci F, Zonari E, Sitia G, Mazzoleni S, Moi D, Venneri MA, Indraccolo S, et al: Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell. 14:299–311. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Galdiero MR, Bonavita E, Barajon I, Garlanda C, Mantovani A and Jaillon S: Tumor associated macrophages and neutrophils in cancer. Immunobiology. 218:1402–1410. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Matsushima H, Geng S, Lu R, Okamoto T, Yao Y, Mayuzumi N, Kotol PF, Chojnacki BJ, Miyazaki T, Gallo RL, et al: Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells. Blood. 121:1677–1689. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Geng S, Matsushima H, Okamoto T, Yao Y, Lu R, Page K, Blumenthal RM, Ward NL, Miyazaki T and Takashima A: Emergence, origin, and function of neutrophil-dendritic cell hybrids in experimentally induced inflammatory lesions in mice. Blood. 121:1690–1700. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Haen SP, Pereira PL, Salih HR, Rammensee HG and Gouttefangeas C: More than just tumor destruction: Immunomodulation by thermal ablation of cancer. Clin Dev Immunol. 2011:1602502011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Xu SF, Xu M and Yu XC: Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma. Mol Clin Oncol 3: 495-500, 2015.
APA
Chen, Y., Xu, S., Xu, M., & Yu, X. (2015). Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma. Molecular and Clinical Oncology, 3, 495-500. https://doi.org/10.3892/mco.2015.528
MLA
Chen, Y., Xu, S., Xu, M., Yu, X."Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma". Molecular and Clinical Oncology 3.3 (2015): 495-500.
Chicago
Chen, Y., Xu, S., Xu, M., Yu, X."Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma". Molecular and Clinical Oncology 3, no. 3 (2015): 495-500. https://doi.org/10.3892/mco.2015.528
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Xu SF, Xu M and Yu XC: Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma. Mol Clin Oncol 3: 495-500, 2015.
APA
Chen, Y., Xu, S., Xu, M., & Yu, X. (2015). Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma. Molecular and Clinical Oncology, 3, 495-500. https://doi.org/10.3892/mco.2015.528
MLA
Chen, Y., Xu, S., Xu, M., Yu, X."Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma". Molecular and Clinical Oncology 3.3 (2015): 495-500.
Chicago
Chen, Y., Xu, S., Xu, M., Yu, X."Postoperative infection and survival in osteosarcoma patients: Reconsideration of immunotherapy for osteosarcoma". Molecular and Clinical Oncology 3, no. 3 (2015): 495-500. https://doi.org/10.3892/mco.2015.528
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