Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy

  • Authors:
    • Makoto Ishitobi
    • Mizuho Shiba
    • Takahiro Nakayama
    • Hiroki Koyama
    • Yasuhiro Tamaki
  • View Affiliations

  • Published online on: March 30, 2015     https://doi.org/10.3892/mco.2015.534
  • Pages: 843-846
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Abstract

The effect of prior endocrine therapy on tumor biology and clinical outcomes of locoregional recurrence remains unclear. A total of 76 patients, who underwent salvage breast surgery for estrogen receptor‑positive ipsilateral breast tumor recurrence (IBTR) following breast‑conserving surgery for primary breast cancer, were retrospectively reviewed to investigate the association of human epidermal growth factor receptor 2 (HER2) status with the characteristics of IBTR and clinical outcomes following resection of IBTR. There was a tendency for more patients with HER2‑positive IBTR to show resistance to endocrine therapy (71.4%) compared with those with HER2‑negative IBTR (37.3%) (P=0.085). Patients with HER2‑positive IBTR exhibited a higher rate of recurrence (62.5%) compared with those with HER2‑negative IBTR (25.0%) (P=0.027). These results suggested that HER2‑positive IBTR may be associated with resistance to endocrine therapy and a poorer clinical outcome.
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July-2015
Volume 3 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Ishitobi M, Shiba M, Nakayama T, Koyama H and Tamaki Y: Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy. Mol Clin Oncol 3: 843-846, 2015
APA
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., & Tamaki, Y. (2015). Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy. Molecular and Clinical Oncology, 3, 843-846. https://doi.org/10.3892/mco.2015.534
MLA
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., Tamaki, Y."Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy". Molecular and Clinical Oncology 3.4 (2015): 843-846.
Chicago
Ishitobi, M., Shiba, M., Nakayama, T., Koyama, H., Tamaki, Y."Association of human epidermal growth factor receptor 2 status with ipsilateral breast tumor recurrence and resistance to endocrine therapy". Molecular and Clinical Oncology 3, no. 4 (2015): 843-846. https://doi.org/10.3892/mco.2015.534