Interferon‑β and temozolomide combination therapy for temozolomide monotherapy‑refractory malignant gliomas

  • Authors:
    • Hiroshi Kawaji
    • Tsutomu Tokuyama
    • Tomohiro Yamasaki
    • Shinji Amano
    • Naoto Sakai
    • Hiroki Namba
  • View Affiliations

  • Published online on: April 8, 2015     https://doi.org/10.3892/mco.2015.542
  • Pages: 909-913
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Abstract

Interferon‑β (IFN‑β) has been found to downregulate O6‑methyl‑guanine‑DNA methyltransferase and sensitize glioma cells to chemoradiation therapy. The effectiveness of IFN‑β and temozolomide (TMZ) combination therapy for newly diagnosed glioblastomas was previously reported. However, there is no clinical report of recurrent of malignant gliomas treated with the combination of IFN‑β and TMZ. In the present study, we reported 7 cases of gliomas classified as uncontrollable with adjuvant TMZ monotherapy, who were then treated with IFN‑β and TMZ combination therapy. The magnetic resonance imaging findings and clinical symptoms improved in the majority of the cases, with tolerable adverse events and minimal residual disability. The overall survival (OS) time from the date of the initial surgery exceeded 13 months, suggesting that this combination therapy was successful in improving the prognosis of malignant gliomas refractory to adjuvant TMZ monotherapy.
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July-2015
Volume 3 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Kawaji H, Tokuyama T, Yamasaki T, Amano S, Sakai N and Namba H: Interferon‑β and temozolomide combination therapy for temozolomide monotherapy‑refractory malignant gliomas. Mol Clin Oncol 3: 909-913, 2015
APA
Kawaji, H., Tokuyama, T., Yamasaki, T., Amano, S., Sakai, N., & Namba, H. (2015). Interferon‑β and temozolomide combination therapy for temozolomide monotherapy‑refractory malignant gliomas. Molecular and Clinical Oncology, 3, 909-913. https://doi.org/10.3892/mco.2015.542
MLA
Kawaji, H., Tokuyama, T., Yamasaki, T., Amano, S., Sakai, N., Namba, H."Interferon‑β and temozolomide combination therapy for temozolomide monotherapy‑refractory malignant gliomas". Molecular and Clinical Oncology 3.4 (2015): 909-913.
Chicago
Kawaji, H., Tokuyama, T., Yamasaki, T., Amano, S., Sakai, N., Namba, H."Interferon‑β and temozolomide combination therapy for temozolomide monotherapy‑refractory malignant gliomas". Molecular and Clinical Oncology 3, no. 4 (2015): 909-913. https://doi.org/10.3892/mco.2015.542