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Article

Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia

  • Authors:
    • Wen Du
    • Yanjie Hu
    • Cong Lu
    • Juan Li
    • Wei Liu
    • Yanli He
    • Ping Wang
    • Chen Cheng
    • Yu Hu
    • Shiang Huang
    • Junxia Yao
    • Jin'e Zheng
  • View Affiliations / Copyright

    Affiliations: Center for Stem Cell Research and Application, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Tumor Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 833-838
    |
    Published online on: April 24, 2015
       https://doi.org/10.3892/mco.2015.552
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Abstract

Resistance to chemotherapy is a major challenge for leukemia treatment. It has been suggested that leukemia stem cells (LSCs), a small pool of self‑renewing leukemic cells, play important roles in development of chemotherapy resistance. The expression of cluster of differentiation 96 (CD96), a potential marker for LSCs, was investigated in CD34+CD38‑ cells of 105 acute leukemia (AL) patients by flow cytometry. The data showed that all the CD34+, CD34+CD38‑ and CD34+CD38‑CD96+ proportions were much higher in AL compared to the normal control (P<0.01), while a clear difference was identified in the CD34+CD38‑ and CD34+CD38‑CD96+ proportions between acute lymphoid leukemia and acute myeloid leukemia (AML). However, all the AML patients with >15% CD34+CD38‑ cells achieved complete remission (CR), suggesting that as an LSC‑rich population, the amount of CD34+CD38‑ cells may not be positively associated with the proportion of refractory LSCs. The mean percentage of the co‑presence of CD96 expression itself was similar in AML patients with CR and non‑CR (P>0.05). However, the CR rate was significantly higher in the AML population with <10% CD96 expressed, which indicated that a distinct sub‑group of CD34+CD38‑CD96+ cells may still contribute to the drug resistance or poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Du W, Hu Y, Lu C, Li J, Liu W, He Y, Wang P, Cheng C, Hu Y, Huang S, Huang S, et al: Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia. Mol Clin Oncol 3: 833-838, 2015.
APA
Du, W., Hu, Y., Lu, C., Li, J., Liu, W., He, Y. ... Zheng, J. (2015). Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia. Molecular and Clinical Oncology, 3, 833-838. https://doi.org/10.3892/mco.2015.552
MLA
Du, W., Hu, Y., Lu, C., Li, J., Liu, W., He, Y., Wang, P., Cheng, C., Hu, Y., Huang, S., Yao, J., Zheng, J."Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia". Molecular and Clinical Oncology 3.4 (2015): 833-838.
Chicago
Du, W., Hu, Y., Lu, C., Li, J., Liu, W., He, Y., Wang, P., Cheng, C., Hu, Y., Huang, S., Yao, J., Zheng, J."Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia". Molecular and Clinical Oncology 3, no. 4 (2015): 833-838. https://doi.org/10.3892/mco.2015.552
Copy and paste a formatted citation
x
Spandidos Publications style
Du W, Hu Y, Lu C, Li J, Liu W, He Y, Wang P, Cheng C, Hu Y, Huang S, Huang S, et al: Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia. Mol Clin Oncol 3: 833-838, 2015.
APA
Du, W., Hu, Y., Lu, C., Li, J., Liu, W., He, Y. ... Zheng, J. (2015). Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia. Molecular and Clinical Oncology, 3, 833-838. https://doi.org/10.3892/mco.2015.552
MLA
Du, W., Hu, Y., Lu, C., Li, J., Liu, W., He, Y., Wang, P., Cheng, C., Hu, Y., Huang, S., Yao, J., Zheng, J."Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia". Molecular and Clinical Oncology 3.4 (2015): 833-838.
Chicago
Du, W., Hu, Y., Lu, C., Li, J., Liu, W., He, Y., Wang, P., Cheng, C., Hu, Y., Huang, S., Yao, J., Zheng, J."Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia". Molecular and Clinical Oncology 3, no. 4 (2015): 833-838. https://doi.org/10.3892/mco.2015.552
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