Computed tomography imaging characteristics of synchronous gastrointestinal stromal tumors in patients with gastric cancer and correlation with clinicopathological findings
- Authors:
View Affiliations
Affiliations: Department of Radiology, The First Affiliated Hospital of Fujian Medical University, P.R. China, Department of Pharmacy, Union Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China
- Published online on: August 13, 2015 https://doi.org/10.3892/mco.2015.621
-
Pages:
1311-1314
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
This study was conducted to analyze the computed tomography (CT) imaging and clinicopathological characteristics of synchronous gastrointestinal stromal tumors (GISTs) in patients with gastric cancer. We retrospectively reviewed the CT images in 18 cases of immunohistochemically confirmed synchronous GISTs in patients with primary gastric cancer. Relevant histology and clinical data were also obtained. Multi‑slice CT (MSCT) identified suspected synchronous GISTs in 26 patients, of which 18 were finally confirmed. Of the 18 patients, 12 were male and 6 female, with a mean age of 69.2 years. All 18 lesions were discovered as a solitary mass, ranging in size from 1.0 to 6.5 cm (mean, 2.2 cm). The lesions were predominantly located in the gastric fundus and were characterized by an ovoid shape, well-defined margins and isodensity, with slight to moderate gradual enhancement on MSCT. There was no evidence of necrosis, hemorrhage or cystic degeneration, irrespective of the tumor size. Synchronous GISTs exhibited spindle cell morphological characteristics and specific immunohistochemical properties, and were classified as being of low or very low malignant potential. In conclusion, since gastric cancer patients with a synchronous GIST are rare, a solitary, ovoid and well-defined mass with slight to moderate gradual enhancement following contrast agent injection may be suggestive of this diagnosis, although detection of synchronous GISTs does not appear to significantly affect therapy and outcome.
View References
|
1
|
Rabin I, Chikman B, Lavy R, Sandbank J,
Maklakovsky M, GoldDeutch R, Halpren Z, Wassermann I and Halevy A:
Gastrointestinal stromal tumors: A 19 year experience. Isr Med
Assoc J. 11:98–102. 2009.PubMed/NCBI
|
|
2
|
Maiorana A, Fante R, Maria Cesinaro A and
Adriana Fano R: Synchronous occurrence of epithelial and stromal
tumors in the stomach: A report of 6 cases. Arch Pathol Lab Med.
124:682–686. 2000.PubMed/NCBI
|
|
3
|
Rauf F, Ahmad Z, Muzzafar S and Hussaini
AS: Synchronous occurrence of gastrointestinal stromal tumor and
gastric adenocarcinoma: A case report. J Pak Med Assoc. 56:184–186.
2006.PubMed/NCBI
|
|
4
|
Al Brahim N, Radhi J and Gately J:
Synchronous epithelioid stromal tumour and lipoma in the stomach.
Can J Gastroenterol. 17:374–375. 2003.PubMed/NCBI
|
|
5
|
Bircan S, Candir O, Aydin S, Başpinar S,
Bülbül M, Kapucuoğlu N, Karahan N and Ciriş M: Synchronous primary
adenocarcinoma and gastrointestinal stromal tumor in the stomach: A
report of two cases. Turk J Gastroenterol. 15:187–191.
2004.PubMed/NCBI
|
|
6
|
Liu SW, Chen GH and Hsieh PP: Collision
tumor of the stomach: a case report of mixed gastrointestinal
stromal tumor and adenocarcinoma. J Clin Gastroenterol. 35:332–334.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Yamamoto D, Hamada Y, Tsubota Y, Kawakami
K, Yamamoto C and Yamamoto M: Simultaneous development of
adenocarcinoma and gastrointestinal stromal tumor (GIST) in the
stomach: Case report. World J Surg Oncol. 10:62012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Ulusan S, Koc Z and Kayaselcuk F:
Gastrointestinal stromal tumours: CT findings. Br J Radiol.
81:618–623. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Fletcher CD, Berman JJ, Corless C,
Gorstein F, Lasota J, Longley BJ, Miettinen M, OLeary TJ, Remotti
H, Rubin BP, et al: Diagnosis of gastrointestinal stromal tumors: A
consensus approach. Int J Surg Pathol. 10:81–89. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Miettinen M, El Rifai WHL, Sobin L and
Lasota J: Evaluation of malignancy and prognosis of
gastrointestinal stromal tumors: A review. Hum Pathol. 33:478–483.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lin YL, Tzeng JE, Wei CK and Lin CW: Small
gastrointestinal stromal tumor concomitant with early gastric
cancer: A case report. World J Gastroenterol. 12:815–817.
2006.PubMed/NCBI
|
|
12
|
Andea AA, Lucas C, Cheng JD and Adsay NV:
Synchronous occurrence of epithelial and stromal tumors in the
stomach. Arch Pathol Lab Med. 125:318–319. 2001.PubMed/NCBI
|
