Evaluation of in vivo efficacy of radiofrequency ablation with D-sorbitol in animal liver

Morishita,Asahiro; Sakamoto,Teppei; Kobara,Hideki; Tadokoro,Tomoko; Ohura,Kyoko; Fujita,Koji; Tani,Joji; Miyoshi,Hisaaki; Yoneyama,Hirohito; Himoto,Takashi; Masaki,Tsutomu

doi:10.3892/mco.2015.680

Evaluation of in vivo efficacy of radiofrequency ablation with D-sorbitol in animal liver

Authors:
- Asahiro Morishita
- Teppei Sakamoto
- Hideki Kobara
- Tomoko Tadokoro
- Kyoko Ohura
- Koji Fujita
- Joji Tani
- Hisaaki Miyoshi
- Hirohito Yoneyama
- Takashi Himoto
- Tsutomu Masaki
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Affiliations: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa 761-0793, P.R. China, Department of Medical Technology, Kagawa Prefectual University of Health Sciences, Takamatsu, Kagawa 761-0123, Japan
Published online on: November 16, 2015 https://doi.org/10.3892/mco.2015.680
Pages: 183-186

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Abstract

Percutaneous radiofrequency ablation (RFA) enables cauterization of liver cancer in a limited number of sessions without major complications. In contrast to the efficacy of this technique, the size of coagulation necrosis is limited due to increased impedance. D-sorbitol has been used as an irrigating fluid during transurethral resection of the prostate, since it is considered to be a dielectric fluid. In order to determine whether D-sorbitol enhances the effect of RFA, RFA was performed by slowly injecting 3% D-sorbitol near the tip of the RFA needle. The maximum of the total injected volume of D-sorbitol was 20 ml and RFA was terminated if the threshold of impedance was exceeded. RFA and D-sorbitol RFA were performed in 5 different parts of pig livers and dog livers in vivo. The total volumes of coagulation necrosis in the D-sorbitol RFA group were significantly higher compared with those in the RFA group. The total delivered energy in the D-sorbitol RFA group was also higher compared with that in the RFA group, due to the suppression of impedance elevation. No significant complications, such as bleeding or damage, were observed during the D-sorbitol RFA procedure in the in vivo model. In conclusion, RFA combined with D-sorbitol increases the total volume of coagulation necrosis through controlling impedance in the ablated liver and, therefore, D-sorbitol may be useful for the treatment of liver cancers.

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