Novel predictive biomarkers for cervical cancer prognosis

  • Authors:
    • Pablo Moreno‑Acosta
    • Schyrly Carrillo
    • Oscar Gamboa
    • Alfredo Romero‑Rojas
    • Jinneth Acosta
    • Monica Molano
    • Joseph Balart‑Serra
    • Martha Cotes
    • Chloé Rancoule
    • Nicolas Magné
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  • Published online on: October 19, 2016     https://doi.org/10.3892/mco.2016.1055
  • Pages: 792-796
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Abstract

High hypoxic, glycolytic and acidosis metabolisms characterize cervical cancer tumors and have been described to be involved in chemoradioresistance mechanisms. Based on these observations, the present study assessed four selected novel biomarkers on the prognosis of locally advanced cervical carcinoma. A total of 66 patients with stage IIB/IIIB cervical cancer were retrospectively included. The protein expression levels of glucose transporter 1 (GLUT1), carbonic anhydrase 9 (CAIX) and hexokinase 1 (HKII) were investigated by immunohistochemistry on tumor biopsies, hemoglobin was measured and the disease outcome was monitored. A total of 53 patients (80.3%) presented a complete response. For these patients, the protein expression levels of GLUT1, CAIX and HKII were overexpressed. A significant difference was observed (P=0.0127) for hemoglobin levels (≤11 g/dl) in responsive compared with non‑responsive patients. The expression of GLUT1 is associated with a lower rate of both overall and disease‑free survival, with a trend of decreased risk of 1.1x and 1.5x, respectively. Co‑expression of GLUT1 and HKII is associated with a decreased trend risk of 1.6x for overall survival. Patients with hemoglobin levels ≤11 g/dl had a 4.3‑fold risk (P=0.02) in decreasing both to the rate of overall and disease‑free survival. The presence of anemic hypoxia (hemoglobin ≤11 g/dl) and the expression of GLUT1 and/or HKII influence treatment response and are associated with a lower overall and disease‑free survival. The present results demonstrated that these biomarkers may be used as predictive markers and suggested that these metabolic pathways can be used as potential novel therapeutic targets.
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December-2016
Volume 5 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Moreno‑Acosta P, Carrillo S, Gamboa O, Romero‑Rojas A, Acosta J, Molano M, Balart‑Serra J, Cotes M, Rancoule C, Magné N, Magné N, et al: Novel predictive biomarkers for cervical cancer prognosis. Mol Clin Oncol 5: 792-796, 2016
APA
Moreno‑Acosta, P., Carrillo, S., Gamboa, O., Romero‑Rojas, A., Acosta, J., Molano, M. ... Magné, N. (2016). Novel predictive biomarkers for cervical cancer prognosis. Molecular and Clinical Oncology, 5, 792-796. https://doi.org/10.3892/mco.2016.1055
MLA
Moreno‑Acosta, P., Carrillo, S., Gamboa, O., Romero‑Rojas, A., Acosta, J., Molano, M., Balart‑Serra, J., Cotes, M., Rancoule, C., Magné, N."Novel predictive biomarkers for cervical cancer prognosis". Molecular and Clinical Oncology 5.6 (2016): 792-796.
Chicago
Moreno‑Acosta, P., Carrillo, S., Gamboa, O., Romero‑Rojas, A., Acosta, J., Molano, M., Balart‑Serra, J., Cotes, M., Rancoule, C., Magné, N."Novel predictive biomarkers for cervical cancer prognosis". Molecular and Clinical Oncology 5, no. 6 (2016): 792-796. https://doi.org/10.3892/mco.2016.1055