Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta‑analysis

  • Authors:
    • Suoyuan Li
    • Qing Yang
    • Hongsheng Wang
    • Zhuoying Wang
    • Dongqing Zuo
    • Zhengdong Cai
    • Yingqi Hua
  • View Affiliations

  • Published online on: October 27, 2016     https://doi.org/10.3892/mco.2016.1066
  • Pages: 832-838
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A number of studies have investigated the role of serum lactate dehydrogenase (LDH) levels in patients with Ewing's sarcoma, although these have yielded inconsistent and inconclusive results. Therefore, the present study aimed to systematically review the published studies and conduct a meta‑analysis to assess its prognostic value more precisely. Cohort studies assessing the prognostic role of LDH levels in patients with Ewing's sarcoma were included. A pooled hazard ratio (HR) with 95% confidence intervals (CIs) of overall survival (OS) or 5‑year disease‑free survival (DFS) was used to assess the prognostic role of the levels of serum LDH. Nine studies published between 1980 and 2014, with a total of 1,412 patients with Ewing's sarcoma, were included. Six studies, with a total of 644 patients, used OS as the primary endpoint and four studies, with 795 patients, used 5‑year DFS. Overall, the pooled HR evaluating high LDH levels was 2.90 (95% CI: 2.09‑4.04) for OS and 2.40 (95% CI: 1.93‑2.98) for 5‑year DFS. This meta‑analysis demonstrates that high levels of serum LDH are associated with lower OS and 5‑year DFS rates in patients with Ewing's sarcoma. Therefore, serum LDH levels are an effective biomarker of Ewing's sarcoma prognosis.
View Figures
View References

Related Articles

Journal Cover

December-2016
Volume 5 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Yang Q, Wang H, Wang Z, Zuo D, Cai Z and Hua Y: Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta‑analysis. Mol Clin Oncol 5: 832-838, 2016.
APA
Li, S., Yang, Q., Wang, H., Wang, Z., Zuo, D., Cai, Z., & Hua, Y. (2016). Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta‑analysis. Molecular and Clinical Oncology, 5, 832-838. https://doi.org/10.3892/mco.2016.1066
MLA
Li, S., Yang, Q., Wang, H., Wang, Z., Zuo, D., Cai, Z., Hua, Y."Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta‑analysis". Molecular and Clinical Oncology 5.6 (2016): 832-838.
Chicago
Li, S., Yang, Q., Wang, H., Wang, Z., Zuo, D., Cai, Z., Hua, Y."Prognostic significance of serum lactate dehydrogenase levels in Ewing's sarcoma: A meta‑analysis". Molecular and Clinical Oncology 5, no. 6 (2016): 832-838. https://doi.org/10.3892/mco.2016.1066