Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts

  • Authors:
    • Masahisa Kudo
    • Yoshiyuki Yamamoto
    • Yoshikatsu Koga
    • Tetsuya Hamaguchi
    • Tetsuo Akimoto
    • Masahiro Yasunaga
    • Yasuhiro Matsumura
  • View Affiliations

  • Published online on: November 1, 2016     https://doi.org/10.3892/mco.2016.1070
  • Pages: 817-822
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Abstract

Combination therapy with S-1 and cisplatin (CDDP) is the standard chemotherapy for advanced gastric cancer in Japan; however, its administration requires hospitalization for hydration to prevent nephrotoxicity from CDDP. By contrast, NC‑6004 appears to reduce the renal toxicity of CDDP and may be used on an outpatient basis. Thus, the effects of combined treatment with S‑1 and NC‑6004 were compared with those of S‑1 and CDDP in a human gastric cancer model. In vitro cytotoxic effects were investigated in 44As3Luc, MKN45 and MKN74 human gastric cancer cell lines. The effects of NC‑6004 and 5-fluorouracil (5‑FU) were compared with the effects of CDDP and 5‑FU using the combination index method. The in vivo antitumor effects of S‑1/NC‑6004 and S‑1/CDDP were evaluated in mice bearing 44As3Luc xenografts. Both combinations exhibited synergistic activity in MKN45 and MKN74 cells and additive effects in 44As3Luc cells. Moreover, the in vivo antitumor effects did not differ between the S‑1/NC‑6004 and S‑1/CDDP treatment groups. However, a significantly lower body weight loss was observed in S-1/NC-6004-treated mice compared with the S‑1/CDDP‑treated mice. Our data warrant a clinical evaluation of S‑1/NC‑6004 combination therapy.
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December-2016
Volume 5 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Kudo M, Yamamoto Y, Koga Y, Hamaguchi T, Akimoto T, Yasunaga M and Matsumura Y: Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts. Mol Clin Oncol 5: 817-822, 2016
APA
Kudo, M., Yamamoto, Y., Koga, Y., Hamaguchi, T., Akimoto, T., Yasunaga, M., & Matsumura, Y. (2016). Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts. Molecular and Clinical Oncology, 5, 817-822. https://doi.org/10.3892/mco.2016.1070
MLA
Kudo, M., Yamamoto, Y., Koga, Y., Hamaguchi, T., Akimoto, T., Yasunaga, M., Matsumura, Y."Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts". Molecular and Clinical Oncology 5.6 (2016): 817-822.
Chicago
Kudo, M., Yamamoto, Y., Koga, Y., Hamaguchi, T., Akimoto, T., Yasunaga, M., Matsumura, Y."Effect of combined treatment with micelle-incorporated cisplatin (NC-6004) and S-1 on human gastric cancer xenografts". Molecular and Clinical Oncology 5, no. 6 (2016): 817-822. https://doi.org/10.3892/mco.2016.1070