Assessing the feasibility of clinicopathological features of hepatic resection for hepatocellular carcinoma in patients over 80 years of age

Iida,Hiroya; Kaibori,Masaki; Matsui,Kosuke; Ishizaki,Morihiko; Kon,Masanori

doi:10.3892/mco.2016.1079

Assessing the feasibility of clinicopathological features of hepatic resection for hepatocellular carcinoma in patients over 80 years of age

Authors:
- Hiroya Iida
- Masaki Kaibori
- Kosuke Matsui
- Morihiko Ishizaki
- Masanori Kon
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Affiliations: Department of Surgery, Kansai Medical University, Osaka 573‑1010, Japan
Published online on: November 11, 2016 https://doi.org/10.3892/mco.2016.1079
Pages: 29-38
Copyright: © Iida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the clinicopathological features, benefits and problems associated with hepatic resection of hepatocellular carcinoma in patients aged ≥80 years. Between 2006 and 2013, hepatic resection was performed in 395 hepatocellular carcinoma patients, including 351 patients aged <80 years and 44 patients aged ≥80 years. Clinicopathological examination revealed that the tumor size was significantly larger among patients of ≥80 years of age. However, recurrence‑free and cumulative survival rates were similar between the two age groups. The occurrence of post‑operative complications was an independent risk factor for survival among patients ≥80 years of age. In addition, the albumin level was identified as a risk factor for post‑operative complications. The post‑operative transition towards an improvement in the albumin level in the ≥80 years group was significantly lower compared with the <80 years group. It was revealed that hepatic resection was feasible for elderly patients. However, the post‑operative improvement in the albumin levels was less marked among patients ≥80 years of age, and lower albumin levels were associated with post‑operative complications and prognosis. Therefore, elderly patients undergoing hepatic resection should receive peri-operative management including special nutrition.

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