Association of tumor necrosis factor‑α polymorphism with chemotherapy‑induced oral mucositis in patients with esophageal cancer

  • Authors:
    • Kazuhiko Sakamoto
    • Shigeru Takeda
    • Shinsuke Kanekiyo
    • Mitsuo Nishiyama
    • Masahiro Kitahara
    • Tomio Ueno
    • Shigeru Yamamoto
    • Shigefumi Yoshino
    • Shoichi Hazama
    • Naoko Okayama
    • Hiroaki Nagano
  • View Affiliations

  • Published online on: November 14, 2016     https://doi.org/10.3892/mco.2016.1081
  • Pages: 125-129
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Abstract

The purpose of this study was to evaluate the association between tumor necrosis factor (TNF)‑α polymorphisms and oral mucositis (OM) from 5‑fluorouracil (5‑FU) plus cisplatin (CDDP) chemotherapy for esophageal cancer. The rs1799964 polymorphism of TNF‑α was genotyped using the tetra‑primer amplification refractory mutation system polymerase chain reaction. The experimental group comprised 64 patients who received chemotherapy for esophageal cancer between 1997 and 2004; a total of 106 patients between 2005 and 2013 were investigated as the validation group. Univariate analysis of the experimental group revealed that the TT genotype of TNF‑α rs1799964 was significantly higher in patients with grade 1‑4 OM compared with the TC/CC genotypes [univariate odds ratio (OR)=4.0; P=0.029]. Similarly, univariate analysis of the validation group revealed that the percentage of the TT genotype was significantly higher in patients with grade 1‑4 OM compared with the TC/CC genotypes (OR=2.8; P=0.043). This difference in risk was replicated in the validation cohort. Thus, the TT genotype of TNF‑α rs1799964 may be a predictor of chemotherapy‑induced OM in patients with esophageal cancer.
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January-2017
Volume 6 Issue 1

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Spandidos Publications style
Sakamoto K, Takeda S, Kanekiyo S, Nishiyama M, Kitahara M, Ueno T, Yamamoto S, Yoshino S, Hazama S, Okayama N, Okayama N, et al: Association of tumor necrosis factor‑α polymorphism with chemotherapy‑induced oral mucositis in patients with esophageal cancer. Mol Clin Oncol 6: 125-129, 2017
APA
Sakamoto, K., Takeda, S., Kanekiyo, S., Nishiyama, M., Kitahara, M., Ueno, T. ... Nagano, H. (2017). Association of tumor necrosis factor‑α polymorphism with chemotherapy‑induced oral mucositis in patients with esophageal cancer. Molecular and Clinical Oncology, 6, 125-129. https://doi.org/10.3892/mco.2016.1081
MLA
Sakamoto, K., Takeda, S., Kanekiyo, S., Nishiyama, M., Kitahara, M., Ueno, T., Yamamoto, S., Yoshino, S., Hazama, S., Okayama, N., Nagano, H."Association of tumor necrosis factor‑α polymorphism with chemotherapy‑induced oral mucositis in patients with esophageal cancer". Molecular and Clinical Oncology 6.1 (2017): 125-129.
Chicago
Sakamoto, K., Takeda, S., Kanekiyo, S., Nishiyama, M., Kitahara, M., Ueno, T., Yamamoto, S., Yoshino, S., Hazama, S., Okayama, N., Nagano, H."Association of tumor necrosis factor‑α polymorphism with chemotherapy‑induced oral mucositis in patients with esophageal cancer". Molecular and Clinical Oncology 6, no. 1 (2017): 125-129. https://doi.org/10.3892/mco.2016.1081