Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas

Zhang,Jing; Li,Xin; Zhang,Yanyan

doi:10.3892/mco.2016.1092

Correlation of Nedd4-1 and PTEN expression with the invasive capacity of pituitary adenomas

Authors:
- Jing Zhang
- Xin Li
- Yanyan Zhang
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Affiliations: Department of Neurosurgery, Heze Municipal Hospital, Heze, Shandong 274000, P.R. China, Department of Neurosurgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, Liaocheng, Shandong 252000, P.R. China
Published online on: November 24, 2016 https://doi.org/10.3892/mco.2016.1092
Pages: 96-100

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Abstract

The aim of the present study was to correlate the expression of neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) with the invasive capacity of pituitary adenomas. A total of 50 pituitary adenoma tissues and 10 normal pituitary tissues were divided into the invasive group (26 cases), the non‑invasive group (24 cases) and the normal group (10 cases). The expression of NEDD4‑1 and PTEN was determined by immunohistochemistry. NEDD4‑1 was revealed to be located in the nucleus and cytoplasm, whereas PTEN was only located in the cytoplasm. Furthermore, expression of NEDD4‑1 was higher in pituitary adenomas compared with normal pituitary tissues (P<0.05), and higher in the invasive group compared with the non‑invasive group, whereas the opposite trend was observed for PTEN. There was a strong negative correlation between NEDD4‑1 and PTEN expression, indicating a dependency between the two and an association with invasiveness. In conclusion, NEDD4‑1 may serve as a diagnostic and prognostic factor, and as a novel therapeutic target, in pituitary adenomas.

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