Mucinous cystadenocarcinoma of the pancreas with anaplastic carcinoma: A case report and review of the literature

Munekage,Masaya; Kohsaki,Takuhiro; Uemura,Sunao; Kitagawa,Hiroyuki; Namikawa,Tsutomu; Hanazaki,Kazuhiro

doi:10.3892/mco.2016.743

April-2016 Volume 4 Issue 4

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April-2016 Volume 4 Issue 4

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Case Report Open Access

Mucinous cystadenocarcinoma of the pancreas with anaplastic carcinoma: A case report and review of the literature

Authors:
- Masaya Munekage
- Takuhiro Kohsaki
- Sunao Uemura
- Hiroyuki Kitagawa
- Tsutomu Namikawa
- Kazuhiro Hanazaki
View Affiliations / Copyright

Affiliations: Department of Surgery, Kochi Medical School, Kochi University, Nankoku, Kochi 783‑8505, Japan, Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi 783‑8505, Japan

Copyright: © Munekage et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 483-486
|
Published online on: January 27, 2016

https://doi.org/10.3892/mco.2016.743
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Abstract

Few reports of mucinous cystic neoplasm (MCN) in association with anaplastic carcinoma exist. The present study reported an unusual case of a 25‑year‑old female exhibiting large pancreatic MCN with anaplastic carcinoma. Notably, the patient was a Jehovah's Witness and therefore refused any blood transfusions. Preoperative diagnosis was invasive pancreatic MCN measuring 12.5 cm with ascites. Distal pancreatectomy was performed in combination with splenectomy and partial resection of the transverse colon. Intraoperative estimated blood loss was 400 ml, therefore a blood transfusion was not required. The patient had an uneventful postoperative course. The pathological diagnosis was mucinous cystadenocarcinoma of the pancreas with anaplastic carcinoma. Although the patient underwent postoperative adjuvant chemotherapy with gemcitabine and oral fluoropyrimidine (S‑1), recurrence with peritoneal dissemination was detected 20 months following surgery and the patient succumbed to the recurrence 32 months following surgery. To the best of our knowledge, this is the first case report of MCN with anaplastic carcinoma of the pancreas in a Jehovah's Witness patient undergoing pancreatic surgery.

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1	Suzuki Y, Atomi Y, Sugiyama M, Isaji S, Inui K, Kimura W, Sunamura M, Furukawa T, Yanagisawa A, Ariyama J, et al: Cystic neoplasm of the pancreas: A Japanes multi-institutional study of intraductal papillary mucinous tumor and mucinous cystic tumor. Pancreas. 28:241–246. 2004. View Article : Google Scholar : PubMed/NCBI
2	Sugiyama M, Suzuki Y, Abe N and Atomi Y: Surgical treatment of pancreatic cystic neoplasms. Nihon Shokakibyo Gakkai Zasshi. 101:865–871. 2004.(In Japanese). PubMed/NCBI
3	Hakamada K, Miura T, Kimura A, Nara M, Toyoki Y, Narumi S and Sasak M: Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: Report of a case and a review of the literature. World J Gastroenterol. 14:132–135. 2008. View Article : Google Scholar : PubMed/NCBI
4	Pan Z and Wang B: Anaplastic carcinoma of the pancreas associated with a mucinous cystic adenocarcinoma. A case report and review of the literature. JOP. 8:775–782. 2007.PubMed/NCBI
5	Logan SE, Voet RL and Tompkins RK: The malignant potential of mucinous cysts of the pancreas. West J Med. 136:157–162. 1982.PubMed/NCBI
6	Marinho A, Nogueira R, Schmitt F and Sobrinho-Simoes M: Pancreatic mucinous cystadenocarcinoma with a mural nodule of anaplastic carcinoma. Hispathology. 26:284–287. 1995.
7	Lane RB Jr and Sangüeza OP: Anaplastic carcinoma occurring in association with a mucinous cystic neoplasm of the pancreas. Arch Pathol Lab Med. 121:533–535. 1997.PubMed/NCBI
8	Jeon YB, Yun S and Choi D: Transfusion free radical antegrade modular pancreaticoduodenectomy of metastatic neuroendocrine tumor of the pancreas in Jehovah's Witness patient. Ann Surg Treat Res. 88:106–110. 2015. View Article : Google Scholar : PubMed/NCBI
9	Konstantinidis IT, Allen PJ, D'Angelica MI, DeMatteo RP, Fischer ME, Grant F, Fong Y, Kingham TP and Jarnagin WR: Pancreas and liver resection in Jehovah's Witness patient: Feasible and safe. J Am Coll Surg. 217:1101–1107. 2013. View Article : Google Scholar : PubMed/NCBI
10	Japan Pancreas Society (eds): Classification of Pancreatic Carcinoma (3rd). Tokyo: Kanehara & Co., Ltd. 2011.
11	Piccini G, Pasculli A, D'Ambrosio E, Gurrado A, Lissidini G and Testini M: Retrospective comparison of traditional vs. Liga Sure impact dissection during pancreatoduodenectomy: How to save money by using an expensive device. Surg Technol Int. 23:88–93. 2013.PubMed/NCBI
12	Li Y, Jiang Z, Zhang L and Liu G: Gemcitabine and S-1 combination therapy versus gemcitabine alone for locally advanced and metastatic pancreatic cancer: A meta-analysis of randomized controlled trials in Asia. J Chemother. 27:227–234. 2015. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Mucinous cystadenocarcinoma of the pancreas with anaplastic carcinoma: A case report and review of the literature

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