Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
April-2016 Volume 4 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 4 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis

  • Authors:
    • Charis Kalogirou
    • Andrey Svistunov
    • Markus Krebs
    • Eva Maria Lausenmeyer
    • Daniel Vergho
    • Hubertus Riedmiller
    • Arkadius Kocot
  • View Affiliations / Copyright

    Affiliations: Department of Urology and Paediatric Urology, Julius Maximilians University Medical Center of Würzburg, D‑97080 Würzburg, Germany, Department of Urology, University of Regensburg, D‑93053 Regensburg, Germany
  • Pages: 636-642
    |
    Published online on: January 28, 2016
       https://doi.org/10.3892/mco.2016.749
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

The role of maintenance therapy with Gemcitabine (GEM) following cisplatin-based combination chemotherapy (CBCC) in patients with surgically treated advanced urothelial carcinoma (UC) remains to be fully elucidated. In the present case control study, a retrospective analysis was performed to evaluate the role of GEM monotherapy following surgical intervention for advanced UC. Between 1999 and 2013, 38 patients were identified with surgically treated advanced UC after having completed CBCC, who were additionally treated quarterly with two consecutive GEM (1,250 mg/m2) infusions as maintenance therapy. This collective was matched by propensity score matching to a control collective (n=38) that received primary CBCC alone, and the overall survival (OS), cancer‑specific survival (CSS) and progression‑free survival (PFS) rates were determined for the two collectives using Kaplan‑Meier estimates and the log‑rank test. Regression analysis was performed using the Cox proportional hazards model. The median follow‑up time was 37 months (interquartile range: 9‑148). Interestingly, patients treated with GEM following primary chemotherapy had a significantly improved outcome with respect to the 5‑year OS (46.2 vs. 26.4%, P=0.0314) and 5‑year CSS (61.3 vs. 33.4%, P=0.0386) rates. Notably, the 5‑year PFS rate did not differ between the two groups (10.3 vs. 16.1%, P=0.134). It is proposed that additional GEM maintenance monotherapy is able to improve survival rates following primary CBCC in surgically treated patients with advanced UC, suggesting a possible treatment option for patients with, e.g., unclear disease status, or those who would require an active maintenance therapy in the future. Prospective studies should further determine the impact of GEM monotherapy with respect to PFS rates in groups comprising larger numbers of patients.
View Figures

Figure 1

View References

1 

Advanced Bladder Cancer (ABC) Meta-analysis Collaboration: Neoadjuvant chemotherapy in invasive bladder cancer: Update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration. Eur Urol. 48:202–205; discussion 205–206. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Freiha F, Reese J and Torti FM: A randomized trial of radical cystectomy versus radical cystectomy plus cisplatin, vinblastine and methotrexate chemotherapy for muscle invasive bladder cancer. J Urol. 155:495–499; discussion 499–500. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Sonpavde G, Sternberg CN, Rosenberg JE, Hahn NM, Galsky MD and Vogelzang NJ: Second-line systemic therapy and emerging drugs for metastatic transitional-cell carcinoma of the urothelium. Lancet Oncol. 11:861–870. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Albers P, Siener R, Härtlein M, Fallahi M, Haeutle D, Perabo FG, Steiner G, Blatter J and Müller SC: German TCC Study Group of the German Association of Urologic Oncology: Gemcitabine monotherapy as second-line treatment in cisplatin-refractory transitional cell carcinoma-prognostic factors for response and improvement of quality of life. Onkologie. 25:47–52. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Akaza H, Naito S, Usami M, Miki T, Miyanaga N and Taniai H: Japanese Gemcitabine Study Group: Efficacy and safety of gemcitabine monotherapy in patients with transitional cell carcinoma after Cisplatin-containing therapy: A Japanese experience. Jpn J Clin Oncol. 37:201–206. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Matsushima M, Kikuchi E, Masugi Y, Akita H, Miyajima A, Jinzaki M and Oya M: Efficacy and safety of gemcitabine monotherapy in an elderly patient with penile metastasis from bladder carcinoma: A case report. Int Canc Conf J. 2(4): 255–260. 2013. View Article : Google Scholar

7 

Muto S, Abe H, Noguchi T, Sugiura SI, Kitamura K, Isotani S, Ide H, Yamaguchi R, Kamai T and Horie S: Maintenance monotherapy with gemcitabine after standard platinum-based chemotherapy in patients with advanced urothelial cancer. Int J Urol. 22:490–494. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Cheng L, Montironi R, Davidson DD and Lopez-Beltran A: Staging and reporting of urothelial carcinoma of the urinary bladder. Mod Pathol. 22:S70–S95. 2009. View Article : Google Scholar : PubMed/NCBI

9 

von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ and Kerbrat P: Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: Results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol. 18:3068–3077. 2000.PubMed/NCBI

10 

Karasek P, Skacel T, Kocakova I, Bednarik O, Petruzelka L, Melichar B, Bustova I, Spurny V and Trason T: Gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer: A prospective observational study. Expert Opin Pharmacother. 4:581–586. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Ricci S, Antonuzzo A, Galli L, Tibaldi C, Bertuccelli M, Pegna Lopes A, Petruzzelli S, Algeri R, Bonifazi V, Fioretto ML, et al: Gemcitabine monotherapy in elderly patients with advanced non-small cell lung cancer: A multicenter phase II study. Lung Cancer. 27:75–80. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Duvic M, Talpur R, Wen S, Kurzrock R, David CL and Apisarnthanarax N: Phase II evaluation of gemcitabine monotherapy for cutaneous T-cell lymphoma. Clin Lymphoma Myeloma. 7:51–58. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Madan RA, Gulley JL, Fojo T and Dahut WL: Therapeutic cancer vaccines in prostate cancer: The paradox of improved survival without changes in time to progression. Oncologist. 15:969–975. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Hernandez-Ilizaliturri FJ and Czuczman MS: Therapeutic options in relapsed or refractory diffuse large B-cell lymphoma. Part 1. Current treatment approaches. Oncology (Williston Park). 23:546–553. 2009.PubMed/NCBI

15 

Soeda A, Morita-Hoshi Y, Makiyama H, Morizane C, Ueno H, Ikeda M, Okusaka T, Yamagata S, Takahashi N, Hyodo I, et al: Regular dose of gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer. Jpn J Clin Oncol. 39:797–806. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Suzuki E, Kapoor V, Jassar AS, Kaiser LR and Albelda SM: Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res. 11:6713–6721. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Nowak AK, Robinson BW and Lake RA: Gemcitabine exerts a selective effect on the humoral immune response implications for combination chemo-immunotherapy. Cancer Res. 62:2353–2358. 2002.PubMed/NCBI

18 

Bellmunt J, Théodore C, Demkov T, Komyakov B, Sengelov L, Daugaard G and Delgado FM: Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract. J Clin Oncol:. 27:4454–4461. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kalogirou C, Svistunov A, Krebs M, Lausenmeyer EM, Vergho D, Riedmiller H and Kocot A: Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis. Mol Clin Oncol 4: 636-642, 2016.
APA
Kalogirou, C., Svistunov, A., Krebs, M., Lausenmeyer, E.M., Vergho, D., Riedmiller, H., & Kocot, A. (2016). Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis. Molecular and Clinical Oncology, 4, 636-642. https://doi.org/10.3892/mco.2016.749
MLA
Kalogirou, C., Svistunov, A., Krebs, M., Lausenmeyer, E. M., Vergho, D., Riedmiller, H., Kocot, A."Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis". Molecular and Clinical Oncology 4.4 (2016): 636-642.
Chicago
Kalogirou, C., Svistunov, A., Krebs, M., Lausenmeyer, E. M., Vergho, D., Riedmiller, H., Kocot, A."Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis". Molecular and Clinical Oncology 4, no. 4 (2016): 636-642. https://doi.org/10.3892/mco.2016.749
Copy and paste a formatted citation
x
Spandidos Publications style
Kalogirou C, Svistunov A, Krebs M, Lausenmeyer EM, Vergho D, Riedmiller H and Kocot A: Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis. Mol Clin Oncol 4: 636-642, 2016.
APA
Kalogirou, C., Svistunov, A., Krebs, M., Lausenmeyer, E.M., Vergho, D., Riedmiller, H., & Kocot, A. (2016). Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis. Molecular and Clinical Oncology, 4, 636-642. https://doi.org/10.3892/mco.2016.749
MLA
Kalogirou, C., Svistunov, A., Krebs, M., Lausenmeyer, E. M., Vergho, D., Riedmiller, H., Kocot, A."Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis". Molecular and Clinical Oncology 4.4 (2016): 636-642.
Chicago
Kalogirou, C., Svistunov, A., Krebs, M., Lausenmeyer, E. M., Vergho, D., Riedmiller, H., Kocot, A."Maintenance monotherapy with Gemcitabine following cisplatin-based primary combination chemotherapy in surgically treated advanced urothelial carcinoma: A matched-pair single institution analysis". Molecular and Clinical Oncology 4, no. 4 (2016): 636-642. https://doi.org/10.3892/mco.2016.749
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team