Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: Evidence from 7,290 cases and 11,630 controls

Wang,Xiangsheng; Luo,Tong; Ruan,Mingjun; Liu,Pan; Wang,Shiying; Zhu,Wenhao

doi:10.3892/mco.2016.813

Association of the CCDC26 rs4295627 polymorphism with the risk of glioma: Evidence from 7,290 cases and 11,630 controls

Authors:
- Xiangsheng Wang
- Tong Luo
- Mingjun Ruan
- Pan Liu
- Shiying Wang
- Wenhao Zhu
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Affiliations: Department of Nephrology, Jining Hospital of Traditional Chinese Medicine, Jining, Shandong 272037, P.R. China, Department of Neurology, Jining Hospital of Traditional Chinese Medicine, Jining, Shandong 272037, P.R. China, Department of Stomatology, Laiwu Laicheng People's Hospital, Laiwu, Shandong 271199, P.R. China, Department of Oncology, Laiwu Hospital of Traditional Chinese Medicine, Laiwu, Shandong 271199, P.R. China, Department of Neurology, Zibo Hospital of Traditional Chinese Medicine, Zibo, Shandong 255300, P.R. China
Published online on: March 9, 2016 https://doi.org/10.3892/mco.2016.813
Pages: 878-882

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Abstract

Published data on the association between the coiled‑coil domain‑containing 26 (CCDC26) rs4295627 polymorphism and the risk of glioma have been inconclusive. To further investigate this association, a meta‑analysis was performed. By a comprehensive literature search using PubMed and EMBASE databases, a total of 16 case‑control studies were identified for inclusion in the meta‑analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess this association. Our results confirmed that the risk with allele G was higher compared with that with allele T for glioma. The results indicated that the allele G of rs4295627 polymorphism in the CCDC26 gene was associated with increased risk of glioma in the homozygote model (GG vs. TT, OR=1.936, 95 %CI: 1.500‑2.658, P<0.001), the heterozygote model (GT vs. TT, OR=1.323, 95% CI: 1.241‑1.412, P=0.206), the dominant model (GG+GT vs. TT, OR=1.375, 95% CI: 1.256‑1.505, P=0.026), the recessive model (GG vs. GT+TT, OR=1.769, 95% CI: 1.302‑2.403, P<0.001) and the allele model (G vs. T, OR=1.310, 95% CI: 1.185‑1.448, P<0.001). Current evidence suggests that the rs4295627 polymorphism in the CCDC26 gene may contribute to glioma susceptibility. However, further case‑control studies are required to confirm our results.

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