Primary hepatic neuroendocrine tumor: A case report

Morishita,Asahiro; Yoneyama,Hirohito; Nomura,Takako; Sakamoto,Teppei; Fujita,Koji; Tani,Joji; Miyoshi,Hisaaki; Haba,Reiji; Masaki,Tsutomu

doi:10.3892/mco.2016.822

Primary hepatic neuroendocrine tumor: A case report

Authors:
- Asahiro Morishita
- Hirohito Yoneyama
- Takako Nomura
- Teppei Sakamoto
- Koji Fujita
- Joji Tani
- Hisaaki Miyoshi
- Reiji Haba
- Tsutomu Masaki
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Affiliations: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa 761‑0793, Japan, Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa 761‑0793, Japan
Published online on: March 17, 2016 https://doi.org/10.3892/mco.2016.822
Pages: 954-956

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Abstract

We herein present a case of an 87-year-old patient with multiple liver tumors identified on abdominal ultrasound. The assessment performed on admission included physical examination, computed tomography (CT) during hepatic angiography and CT during arterial portography. The examination revealed contrast enhancement of a proportion of the liver tumors (20 mm maximum diameter) during the arterial phase and mild contrast washout of those tumors during the delayed phase. On contrast‑enhanced magnetic resonance imaging using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid, certain liver tumors exhibited contrast enhancement during the early phase and contrast washout during the hepatocyte phase in both lobes. By contrast, no lesions were identified during positron emission tomography imaging of the liver. A liver biopsy was performed and immunohistochemical staining revealed enhanced expression of cytokeratin AE1̸AE3, synaptophysin, chromogranin A and CD56 and no expression of hepatocyte antigen or CΚ7. The mindbomb E3 ubiquitin protein ligase‑1 index was ~2% in most of the tumor. The liver tumors were finally diagnosed as multiple intrahepatic metastases from a primary hepatic neuroendocrine tumor (PHNET). The patient underwent transarterial chemoembolisation with a combination of miriplatin (84 mg) mixed with gelatin sponge particles and lipiodol. To the best of our knowledge, this is the first report of PHNET in an patient aged >85 years.

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