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A comparison between Pap and HPV screening tests and screening methods

  • Authors:
    • Emma Altobelli
    • Giorgio Scarselli
    • Amedeo LattanzI
    • Carmine Fortunato
    • Valerio F. Profeta

  • View Affiliations

  • Published online on: May 23, 2016     https://doi.org/10.3892/mco.2016.909
  • Pages: 348-354
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Abstract

The present study assesses the results of cervical cancer (CC) screening over two 3-year periods (2008-2010 and 2011-2013) by comparing two screening tests [Papanicolaou (Pap) and human papillomavirus (HPV) tests] and two screening methods (organized and spontaneous). The study population includes women aged 25-64 years who underwent CC screening between 2008 and 2010 and/or 2011 and 2013, divided into those who responded to an invitation letter (organized screening) and those who spontaneously underwent testing at a public or private facility (non‑programmed screening). Between 2008 and 2010, the response rates increased from 27.7% in 2008 to 44.5% in 2009 and 67.6% in 2010 (P<0.001). Women aged 25‑34 years had the lowest response rate, whereas respondents were more frequent among women aged 35‑44 and 45‑54 years. Significant differences (P<0.001) were identified between organized and spontaneous screening test results with regard to diagnostic categories high‑grade squamous intraepithelial lesion (50.5 vs. 49.5%), low‑grade squamous intraepithelial lesion (42.8 vs. 57.2%) and undetermined lesion atypical glandular cells (AGC; 57.5 vs. 42.5%) or atypical squamous cells of undetermined significance (ASC‑US; 54.2 vs. 45.8%). Compared with spontaneous screening, the organized programme resulted in a larger number of women screened for CC; it reduced the frequency of undetermined diagnoses (AGC, ASC‑US), and identified a larger number of high-grade lesions.
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August-2016
Volume 5 Issue 2

Print ISSN: 2049-9450
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Spandidos Publications style
Altobelli E, Scarselli G, LattanzI A, Fortunato C and Profeta VF: A comparison between Pap and HPV screening tests and screening methods. Mol Clin Oncol 5: 348-354, 2016
APA
Altobelli, E., Scarselli, G., LattanzI, A., Fortunato, C., & Profeta, V.F. (2016). A comparison between Pap and HPV screening tests and screening methods. Molecular and Clinical Oncology, 5, 348-354. https://doi.org/10.3892/mco.2016.909
MLA
Altobelli, E., Scarselli, G., LattanzI, A., Fortunato, C., Profeta, V. F."A comparison between Pap and HPV screening tests and screening methods". Molecular and Clinical Oncology 5.2 (2016): 348-354.
Chicago
Altobelli, E., Scarselli, G., LattanzI, A., Fortunato, C., Profeta, V. F."A comparison between Pap and HPV screening tests and screening methods". Molecular and Clinical Oncology 5, no. 2 (2016): 348-354. https://doi.org/10.3892/mco.2016.909