Open Access

Consolidation chwemotherapy after concurrent chemoradiotherapy vs. chemoradiotherapy alone for locally advanced unresectable stage III non-small-cell lung cancer: A meta-analysis

  • Authors:
    • Xiu‑Jun Chang
    • Zi‑Tong Wang
    • Lei Yang
  • View Affiliations

  • Published online on: May 23, 2016     https://doi.org/10.3892/mco.2016.910
  • Pages: 271-278
  • Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Concurrent chemoradiotherapy (CCRT) has been considered to be the standard of care for locally advanced unresectable stage III non-small-cell lung cancer (LA-NSCLC). Whether consolidation chemotherapy (CCT) following CCRT is able to further improve the clinical outcome remains unclear. We therefore undertook a meta‑analysis to compare the two regimens for LA‑NSCLC. A literature search was performed through PubMed, Embase, Cochrane Library and Chinese Biology Medicine, from their inception to November, 2015. irrelevant studies were excluded using the Preferred Reporting Items for Systematic Reviews and Meta‑analyses standards. Our primary endpoint was overall survival (OS), which was defined as the time from randomisation until death from any cause; the secondary endpoint was progression‑free survival (PFS). All analyses were by intention‑to‑treat. Five phase III randomized controlled trials with 958 patients were included in the present meta‑analysis. The results were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Compared with CCRT, CCT after CCRT was not associated with statistically significant differences in OS (OR=1.24; 95% CI: 0.89‑1.72; P=0.21) or PFS (OR=1.16; 95% CI: 0.74‑1.83; P=0.53), but increased the risk of toxicity, including infection (P=0.02), pneumonitis (P=0.003) and treatment‑related death (P=0.04). There were no significant differences in terms of benefit according to particular patient characteristics, such as age, gender, performance status, tumor histology or clinical stage. Thus, the present study failed to support the use of CCT after CCRT over CCRT alone, as there was no significant OS and PFS benefit for LA-NSCLC patients, but the use of CCT after CCRT resulted in increased toxicity.
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August-2016
Volume 5 Issue 2

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Online ISSN:2049-9469

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Spandidos Publications style
Chang XJ, Wang ZT and Yang L: Consolidation chwemotherapy after concurrent chemoradiotherapy vs. chemoradiotherapy alone for locally advanced unresectable stage III non-small-cell lung cancer: A meta-analysis. Mol Clin Oncol 5: 271-278, 2016
APA
Chang, X., Wang, Z., & Yang, L. (2016). Consolidation chwemotherapy after concurrent chemoradiotherapy vs. chemoradiotherapy alone for locally advanced unresectable stage III non-small-cell lung cancer: A meta-analysis. Molecular and Clinical Oncology, 5, 271-278. https://doi.org/10.3892/mco.2016.910
MLA
Chang, X., Wang, Z., Yang, L."Consolidation chwemotherapy after concurrent chemoradiotherapy vs. chemoradiotherapy alone for locally advanced unresectable stage III non-small-cell lung cancer: A meta-analysis". Molecular and Clinical Oncology 5.2 (2016): 271-278.
Chicago
Chang, X., Wang, Z., Yang, L."Consolidation chwemotherapy after concurrent chemoradiotherapy vs. chemoradiotherapy alone for locally advanced unresectable stage III non-small-cell lung cancer: A meta-analysis". Molecular and Clinical Oncology 5, no. 2 (2016): 271-278. https://doi.org/10.3892/mco.2016.910