Open Access

Progress in the research on the mechanism of bone metastasis in lung cancer (Review)

  • Authors:
    • Qinqin Luo
    • Zhenye Xu
    • Lifang Wang
    • Mingyu Ruan
    • Guiyu Jin
  • View Affiliations

  • Published online on: June 2, 2016     https://doi.org/10.3892/mco.2016.917
  • Pages: 227-235
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lung cancer is still the predominant cause of cancer-associated mortality worldwide. The bone metastasis of lung cancer brings great suffering to the patient. Previous advances have provided insights into the mechanism of bone metastasis. Previous research has investigated lung cancer stem cells and three steps were determined for the lung cancer cells to metastasize to the bone: i) Escaping from the primary tumor; ii) moving in the circulation; iii) colonizing in the bone. Key molecules are involved in each of these process. Although there is a close association and similarity, dynamic microenvironments affect these processes. The receptor activator of nuclear factor‑κB (RANK)/RANKL axis serves a vital role in the regulation of the generation and activation of osteoclasts during the osteolytic lesion. However, the specific molecules for the lung cancer cells to metastasize to the bone require further research and exploration. The present study aimed to investigate the relative molecular mechanisms of bone metastasis in lung cancer in recent years, providing a general understanding about the features of lung cancer preferences to bone, and discussing other things that require investigation.
View Figures
View References

Related Articles

Journal Cover

August-2016
Volume 5 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Luo Q, Xu Z, Wang L, Ruan M and Jin G: Progress in the research on the mechanism of bone metastasis in lung cancer (Review). Mol Clin Oncol 5: 227-235, 2016.
APA
Luo, Q., Xu, Z., Wang, L., Ruan, M., & Jin, G. (2016). Progress in the research on the mechanism of bone metastasis in lung cancer (Review). Molecular and Clinical Oncology, 5, 227-235. https://doi.org/10.3892/mco.2016.917
MLA
Luo, Q., Xu, Z., Wang, L., Ruan, M., Jin, G."Progress in the research on the mechanism of bone metastasis in lung cancer (Review)". Molecular and Clinical Oncology 5.2 (2016): 227-235.
Chicago
Luo, Q., Xu, Z., Wang, L., Ruan, M., Jin, G."Progress in the research on the mechanism of bone metastasis in lung cancer (Review)". Molecular and Clinical Oncology 5, no. 2 (2016): 227-235. https://doi.org/10.3892/mco.2016.917