Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer

  • Authors:
    • You‑Sheng Wei
    • De‑Sheng Yao
    • Ying Long
  • View Affiliations

  • Published online on: June 24, 2016     https://doi.org/10.3892/mco.2016.941
  • Pages: 307-311
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Abstract

Perineural invasion (PNI) has been investigated as a new prognostic factor in a number of carcinomas. However, studies on PNI in cervical cancer are limited, and inconsistent conclusions have been reported by different groups. The aim of the present study was to analyze the relationship between perineural invasion (PNI) and clinical and histopathological features of cervical cancer, and to evaluate the clinical significance of PNI of cervical cancer. Retrospective review identified 206 patients with cervical cancer who underwent radical hysterectomy plus pelvic lymphadenectomy between December 2012 and August 2014. The association between PNI and clinical and histopathological features of cervical cancer and post‑operative radiotherapy was evaluated based on univariate and multivariate analyses. PNI of cervical cancer was identified in 33 of 206 (16%) cervical cancer patients. Univariate analysis demonstrated that PNI was associated with clinical stage, tumor grade, tumor size, depth of invasion, lymphovascular space invasion (LVSI), and lymph node metastasis (P<0.05), but not associated with age and histopathological types (P>0.05). Multivariate analysis suggests that LVSI and lymph node metastasis were associated with PNI of cervical cancer (P<0.05). In addition, post‑operative radiotherapy was significantly more recommended for patients with PNI than those without PNI (P<0.001). In conclusion, PNI of cervical cancer is associated with LVSI and lymph node metastasis and can be used as an index for the determination of post‑operative radiotherapy for cervical cancer patients.
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September-2016
Volume 5 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Wei YS, Yao DS and Long Y: Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer. Mol Clin Oncol 5: 307-311, 2016
APA
Wei, Y., Yao, D., & Long, Y. (2016). Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer. Molecular and Clinical Oncology, 5, 307-311. https://doi.org/10.3892/mco.2016.941
MLA
Wei, Y., Yao, D., Long, Y."Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer". Molecular and Clinical Oncology 5.3 (2016): 307-311.
Chicago
Wei, Y., Yao, D., Long, Y."Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer". Molecular and Clinical Oncology 5, no. 3 (2016): 307-311. https://doi.org/10.3892/mco.2016.941