Prognostic significance of Tspan9 in gastric cancer

  • Authors:
    • Tongtong Feng
    • Libin Sun
    • Weiwei Qi
    • Fei Pan
    • Jing Lv
    • Jing Guo
    • Shufen Zhao
    • Aiping Ding
    • Wensheng Qiu
  • View Affiliations

  • Published online on: July 15, 2016     https://doi.org/10.3892/mco.2016.961
  • Pages: 231-236
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Abstract

Tetraspanins are a large superfamily of glycoproteins, which are engaged in a wide range of specific molecular interactions by forming tetraspanin-enriched microdomains. Tetraspanin 9 (Tspan9) is a previously poorly studied tetraspanin gene, which was predominantly identified as an amplified gene in serous Fallopian tube carcinoma. However, the expression and role of Tspan9 in gastric cancer have yet to be fully elucidated. The aim of the present study was to evaluate the expression and clinical significance of Tspan9 in gastric cancer. In the present study, 105 gastric cancer tissue samples and corresponding adjacent normal samples were detected for Tspan9 expression using immunohistochemistry; furthermore, the association between clinical characteristics and Tspan9 expression was also analyzed. Tspan9 expression was determined to be significantly lower in cancer samples compared with those in corresponding adjacent normal samples (P<0.001). However, its increased levels of expression in cancer samples appeared to demonstrate a poorer prognostic tendency, which is associated with deeper tumor depth (P=0.025), more nodal involvement (P=0.01), more advanced tumor/lymph node/metastasis (TNM) stages (P=0.017) and a larger tumor size (P=0.026). Additionally, multivariate analysis demonstrated that high expression of Tspan9 was an independent prognostic factor for poor overall survival (P<0.01). These results suggested that Tspan9 may be used as a potential prognostic factor in gastric cancer.
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September-2016
Volume 5 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Feng T, Sun L, Qi W, Pan F, Lv J, Guo J, Zhao S, Ding A and Qiu W: Prognostic significance of Tspan9 in gastric cancer. Mol Clin Oncol 5: 231-236, 2016
APA
Feng, T., Sun, L., Qi, W., Pan, F., Lv, J., Guo, J. ... Qiu, W. (2016). Prognostic significance of Tspan9 in gastric cancer. Molecular and Clinical Oncology, 5, 231-236. https://doi.org/10.3892/mco.2016.961
MLA
Feng, T., Sun, L., Qi, W., Pan, F., Lv, J., Guo, J., Zhao, S., Ding, A., Qiu, W."Prognostic significance of Tspan9 in gastric cancer". Molecular and Clinical Oncology 5.3 (2016): 231-236.
Chicago
Feng, T., Sun, L., Qi, W., Pan, F., Lv, J., Guo, J., Zhao, S., Ding, A., Qiu, W."Prognostic significance of Tspan9 in gastric cancer". Molecular and Clinical Oncology 5, no. 3 (2016): 231-236. https://doi.org/10.3892/mco.2016.961