Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma

  • Authors:
    • Ana Cebollero
    • Teresa Puértolas
    • Isabel Pajares
    • Lourdes Calera
    • Antonio Antón
  • View Affiliations

  • Published online on: August 4, 2016     https://doi.org/10.3892/mco.2016.978
  • Pages: 458-462
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Abstract

A retrospective observational study was conducted on patients diagnosed with serine/threonine-protein kinase B-Raf (BRAF)‑mutated metastatic melanoma, who underwent first‑line therapy with BRAF and mitogen‑activated protein kinase kinase (MEK) inhibitors (vemurafenib, dabrafenib or a combination of dabrafenib and trametinib) at the Miguel Servet University Hospital (Zaragoza, Spain) between November, 2011 and August, 2015. The aim of this study was to analyse the toxicity produced by BRAF and MEK inhibitors. The most common toxicities were similar to those published in clinical trials, particularly arthralgia, alopecia and photosensitivity in the vemurafenib group; asthenia, hyperkeratosis and dry skin in the dabrafenib group; and diarrhoea and dry skin in the dabrafenib plus trametinib group. Toxicities that had not been described in clinical trials were also identified. Thus, the present study confirmed that the results obtained in clinical trials are similar to those obtained in clinical practice.
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October-2016
Volume 5 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Cebollero A, Puértolas T, Pajares I, Calera L and Antón A: Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma. Mol Clin Oncol 5: 458-462, 2016
APA
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., & Antón, A. (2016). Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma. Molecular and Clinical Oncology, 5, 458-462. https://doi.org/10.3892/mco.2016.978
MLA
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., Antón, A."Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma". Molecular and Clinical Oncology 5.4 (2016): 458-462.
Chicago
Cebollero, A., Puértolas, T., Pajares, I., Calera, L., Antón, A."Comparative safety of BRAF and MEK inhibitors (vemurafenib, dabrafenib and trametinib) in first‑line therapy for BRAF‑mutated metastatic melanoma". Molecular and Clinical Oncology 5, no. 4 (2016): 458-462. https://doi.org/10.3892/mco.2016.978