Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report

Hashemi,Seyed Mehdi; Mahmoudi Shan,Shokoufeh; Jahantigh,Mahdi; Allahyari,Abolghasem

doi:10.3892/mco.2017.1124

Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report

Authors:
- Seyed Mehdi Hashemi
- Shokoufeh Mahmoudi Shan
- Mahdi Jahantigh
- Abolghasem Allahyari
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Affiliations: Division of Hematology and Medical Oncology, Department of Internal Medicine, School of Medicine, zahedan university of medical sciences, Zahedan, Iran, Department of Internal Medicine, School of Medicine, Students' Scientific Research Center, Zahedan, Iran, Department of Pathology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran, Division of Hematology and Medical Oncology, Department of Medicine, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran
Published online on: January 3, 2017 https://doi.org/10.3892/mco.2017.1124
Pages: 271-275

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Abstract

Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests of squamous cells in a spindle cell background. Furthermore, its occurrence following AML is also rare. To the best of our knowledge, based on a review of the relevant literature, thus far there have not been any welldocumented cases. In the present case report, we report on a middle-aged woman with a 2year history of acute myeloid leukemia (AML) who was admitted to hospital due to a mass in the right breast, with concurrent cutaneous lesions on the breast. The clinical and pathological investigations resulted in the diagnosis of adenosquamous carcinoma of the breast. The patient underwent a modified radical mastectomy (MRM). Subsequently, the patient received chemotherapy, involved-field radiation therapy and target therapy. At 9 months after the final cycle of chemotherapy, and while she was on targeted therapy with trastuzumab (6 mg administered every 3 weeks), the patient presented with extensive dermatomal skin lesions. A biopsy report revealed metastatic lesions of invasive ductal carcinoma in the abdomen, so chemotherapy resumed with a course lasting for 6 cycles, with the identical treatments, but lacking trastuzumab.

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