The role of peroxiredoxins in cancer (Review)
- Authors:
- Arianna Nicolussi
- Sonia D'inzeo
- Carlo Capalbo
- Giuseppe Giannini
- Anna Coppa
-
Affiliations: Department of Experimental Medicine, Sapienza University of Rome, I‑00161 Rome, Italy, Department of Molecular Medicine, Sapienza University of Rome, I‑00161 Rome, Italy - Published online on: January 10, 2017 https://doi.org/10.3892/mco.2017.1129
- Pages: 139-153
-
Copyright: © Nicolussi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84. 2007. View Article : Google Scholar : PubMed/NCBI | |
Duracková Z: Some current insights into oxidative stress. Physiol Res. 59:459–469. 2010.PubMed/NCBI | |
Xing M: Oxidative stress: A new risk factor for thyroid cancer. Endocr Relat Cancer. 19:C7–C11. 2012. View Article : Google Scholar : PubMed/NCBI | |
Dröge W: Free radicals in the physiological control of cell function. Physiol Rev. 82:47–95. 2002. View Article : Google Scholar : PubMed/NCBI | |
Giorgio M, Trinei M, Migliaccio E and Pelicci PG: Hydrogen peroxide: A metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol. 8:722–728. 2007. View Article : Google Scholar : PubMed/NCBI | |
Rhee SG, Bae YS, Lee SR and Kwon J: Hydrogen peroxide: A key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE. 2000:pe12000.PubMed/NCBI | |
Cha MK, Kim HK and Kim IH: Thioredoxin-linked ‘thiol peroxidase’ from periplasmic space of Escherichia coli. J Biol Chem. 270:28635–28641. 1995. View Article : Google Scholar : PubMed/NCBI | |
Zhou Y, Wan XY, Wang HL, Yan ZY, Hou YD and Jin DY: Bacterial scavengase p20 is structurally and functionally related to peroxiredoxins. Biochem Biophys Res Commun. 233:848–852. 1997. View Article : Google Scholar : PubMed/NCBI | |
Nogoceke E, Gommel DU, Kiess M, Kalisz HM and Flohé L: A Unique cascade of oxidoreductases catalyses trypanothione-mediated peroxide metabolism in Crithidia fasciculata. Biol Chem. 378:827–836. 1997. View Article : Google Scholar : PubMed/NCBI | |
Bryk R, Griffin P and Nathan C: Peroxynitrite reductase activity of bacterial peroxiredoxins. Nature. 407:211–215. 2000. View Article : Google Scholar : PubMed/NCBI | |
Hillas PJ, del Alba FS, Oyarzabal J, Wilks A and De Montellano PR Ortiz: The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis. J Biol Chem. 275:18801–18809. 2000. View Article : Google Scholar : PubMed/NCBI | |
Karplus PA: A primer on peroxiredoxin biochemistry. Free Radic Biol Med. 80:183–190. 2015. View Article : Google Scholar : PubMed/NCBI | |
Winterbourn CC: Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol. 4:278–286. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kim K, Kim IH, Lee KY, Rhee SG and Stadtman ER: The isolation and purification of a specific ‘protector’ protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. J Biol Chem. 263:4704–4711. 1988.PubMed/NCBI | |
Chae HZ, Robison K, Poole LB, Church G, Storz G and Rhee SG: Cloning and sequencing of thiol-specific antioxidant from mammalian brain: Alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc Natl Acad Sci USA. 91:7017–7021. 1994. View Article : Google Scholar : PubMed/NCBI | |
Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, et al: Peroxiredoxins are conserved markers of circadian rhythms. Nature. 485:459–464. 2012.PubMed/NCBI | |
Nelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB and Fetrow JS: Analysis of the peroxiredoxin family: Using active-site structure and sequence information for global classification and residue analysis. Proteins. 79:947–964. 2011. View Article : Google Scholar : PubMed/NCBI | |
Perkins A, Gretes MC, Nelson KJ, Poole LB and Karplus PA: Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes. Biochemistry. 51:7638–7650. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hall A, Nelson K, Poole LB and Karplus PA: Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Antioxid Redox Signal. 15:795–815. 2011. View Article : Google Scholar : PubMed/NCBI | |
Dammeyer P and Arnér ES: Human protein atlas of redox systems-what can be learnt? Biochim Biophys Acta. 1810:111–138. 2011. View Article : Google Scholar : PubMed/NCBI | |
Rhee SG, Chae HZ and Kim K: Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med. 38:1543–1552. 2005. View Article : Google Scholar : PubMed/NCBI | |
Seo MS, Kang SW, Kim K, Baines IC, Lee TH and Rhee SG: Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. J Biol Chem. 275:20346–20354. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kang SW, Baines IC and Rhee SG: Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. J Biol Chem. 273:6303–6311. 1998. View Article : Google Scholar : PubMed/NCBI | |
Fujii J, Ikeda Y, Kurahashi T and Homma T: Physiological and pathological views of peroxiredoxin 4. Free Radic Biol Med. 83:373–379. 2015. View Article : Google Scholar : PubMed/NCBI | |
Rhee SG, Kang SW, Chang TS, Jeong W and Kim K: Peroxiredoxin, a novel family of peroxidases. IUBMB Life. 52:35–41. 2001. View Article : Google Scholar : PubMed/NCBI | |
Hofmann B, Hecht HJ and Flohé L: Peroxiredoxins. Biol Chem. 383:347–364. 2002. View Article : Google Scholar : PubMed/NCBI | |
Declercq JP, Evrard C, Clippe A, Stricht DV, Bernard A and Knoops B: Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. J Mol Biol. 311:751–759. 2001. View Article : Google Scholar : PubMed/NCBI | |
Monteiro G, Horta BB, Pimenta DC, Augusto O and Netto LE: Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C. Proc Natl Acad Sci USA. 104:4886–4891. 2007. View Article : Google Scholar : PubMed/NCBI | |
Karplus PA and Hall A: Structural survey of the peroxiredoxins. Subcell Biochem. 44:41–60. 2007. View Article : Google Scholar : PubMed/NCBI | |
Wood ZA, Poole LB, Hantgan RR and Karplus PA: Dimers to Doughnuts: Redox-sensitive oligomerization of 2-cysteine peroxiredoxins. Biochemistry. 41:5493–5504. 2002. View Article : Google Scholar : PubMed/NCBI | |
Barranco-Medina S, Lázaro JJ and Dietz KJ: The oligomeric conformation of peroxiredoxins links redox state to function. FEBS Lett. 583:1809–1816. 2009. View Article : Google Scholar : PubMed/NCBI | |
Fujii J and Ikeda Y: Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. Redox Rep. 7:123–130. 2002. View Article : Google Scholar : PubMed/NCBI | |
Pisoschi AM and Pop A: The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem. 97:55–74. 2015. View Article : Google Scholar : PubMed/NCBI | |
Fulda S, Gorman AM, Hori O and Samali A: Cellular stress responses: Cell survival and cell death. Int J Cell Biol. 2010:2140742010. View Article : Google Scholar : PubMed/NCBI | |
Kamiguti AS, Serrander L, Lin K, Harris RJ, Cawley JC, Allsup DJ, Slupsky JR, Krause KH and Zuzel M: Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol. 175:8424–8430. 2005. View Article : Google Scholar : PubMed/NCBI | |
Tsao SM, Yin MC and Liu WH: Oxidant stress and B vitamins status in patients with non-small cell lung cancer. Nutr Cancer. 59:8–13. 2007. View Article : Google Scholar : PubMed/NCBI | |
Khandrika L, Kumar B, Koul S, Maroni P and Koul HK: Oxidative stress in prostate cancer. Cancer Lett. 282:125–136. 2009. View Article : Google Scholar : PubMed/NCBI | |
Patel BP, Rawal UM, Dave TK, Rawal RM, Shukla SN, Shah PM and Patel PS: Lipid peroxidation, total antioxidant status, and total thiol levels predict overall survival in patients with oral squamous cell carcinoma. Integr Cancer Ther. 6:365–372. 2007. View Article : Google Scholar : PubMed/NCBI | |
Szatrowski TP and Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51:794–798. 1991.PubMed/NCBI | |
Nishikawa M: Reactive oxygen species in tumor metastasis. Cancer Lett. 266:53–59. 2008. View Article : Google Scholar : PubMed/NCBI | |
Clerkin JS, Naughton R, Quiney C and Cotter TG: Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett. 266:30–36. 2008. View Article : Google Scholar : PubMed/NCBI | |
Krstić J, Trivanović D, Mojsilović S and Santibanez JF: Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and cancer progression. Oxid Med Cell Longev. 2015:6545942015. View Article : Google Scholar : PubMed/NCBI | |
Ushio-Fukai M and Nakamura Y: Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett. 266:37–52. 2008. View Article : Google Scholar : PubMed/NCBI | |
Fiaschi T and Chiarugi P: Oxidative stress, tumor microenvironment, and metabolic reprogramming: A diabolic liaison. Int J Cell Biol. 2012:7628252012. View Article : Google Scholar : PubMed/NCBI | |
Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI | |
Weinberg F and Chandel NS: Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci. 66:3663–3673. 2009. View Article : Google Scholar : PubMed/NCBI | |
Cairns RA, Harris IS and Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer. 11:85–95. 2011. View Article : Google Scholar : PubMed/NCBI | |
Park MH, Jo M, Kim YR, Lee CK and Hong JT: Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases. Pharmacol Ther. 163:1–23. 2016. View Article : Google Scholar : PubMed/NCBI | |
Taguchi K, Motohashi H and Yamamoto M: Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells. 16:123–140. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kwee JK: A paradoxical chemoresistance and tumor suppressive role of antioxidant in solid cancer cells: A strange case of Dr. Jekyll and Mr. Hyde. Biomed Res Int. 2014:2098452014. View Article : Google Scholar : PubMed/NCBI | |
Neumann CA, Cao J and Manevich Y: Peroxiredoxin 1 and its role in cell signaling. Cell Cycle. 8:4072–4078. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y and Park YM: Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: Implication to tumor biology. Cancer Res. 67:546–554. 2007. View Article : Google Scholar : PubMed/NCBI | |
Thélie A, Papillier P, Pennetier S, Perreau C, Traverso JM, Uzbekova S, Mermillod P, Joly C, Humblot P and Dalbiès-Tran R: Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo. BMC Dev Biol. 7:1252007. View Article : Google Scholar : PubMed/NCBI | |
Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH and Van Etten RA: Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 424:561–565. 2003. View Article : Google Scholar : PubMed/NCBI | |
Egler RA, Fernandes E, Rothermund K, Sereika S, de Souza-Pinto N, Jaruga P, Dizdaroglu M and Prochownik EV: Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1. Oncogene. 24:8038–8050. 2005. View Article : Google Scholar : PubMed/NCBI | |
Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C and Neumann CA: Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J. 28:1505–1517. 2009. View Article : Google Scholar : PubMed/NCBI | |
O'Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O'Connor DP, Brennan DJ, Connor K, et al: Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer. Breast Cancer Res. 16:R792014. View Article : Google Scholar : PubMed/NCBI | |
Park YH, Kim SU, Lee BK, Kim HS, Song IS, Shin HJ, Han YH, Chang KT, Kim JM, Lee DS, et al: Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. Antioxid Redox Signal. 19:482–496. 2013. View Article : Google Scholar : PubMed/NCBI | |
Godfrey R, Arora D, Bauer R, Stopp S, Müller JP, Heinrich T, Böhmer SA, Dagnell M, Schnetzke U, Scholl S, et al: Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/PTPRJ. Blood. 119:4499–4511. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kim JH, Bogner PN, Baek SH, Ramnath N, Liang P, Kim HR, Andrews C and Park YM: Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. Clin Cancer Res. 14:2326–2333. 2008. View Article : Google Scholar : PubMed/NCBI | |
Quan C, Cha EJ, Lee HL, Han KH, Lee KM and Kim WJ: Enhanced expression of peroxiredoxin I and VI correlates with development, recurrence and progression of human bladder cancer. J Urol. 175:1512–1516. 2006. View Article : Google Scholar : PubMed/NCBI | |
Chung KH, Lee DH, Kim Y, Kim TH, Huh JH, Chung SG, Lee S, Lee C, Ko JJ and An HJ: Proteomic identification of overexpressed PRDX 1 and its clinical implications in ovarian carcinoma. J Proteome Res. 9:451–457. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ren P, Ye H, Dai L, Liu M, Liu X, Chai Y, Shao Q, Li Y, Lei N, Peng B, et al: Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma. Oncol Rep. 30:2297–2303. 2013.PubMed/NCBI | |
Zhou J, Shen W, He X, Qian J, Liu S and Yu G: Overexpression of Prdx1 in hilar cholangiocarcinoma: A predictor for recurrence and prognosis. Int J Clin Exp Pathol. 8:9863–9874. 2015.PubMed/NCBI | |
Sun YL, Cai JQ, Liu F, Bi XY, Zhou LP and Zhao XH: Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer. World J Gastroenterol. 21:10840–10852. 2015. View Article : Google Scholar : PubMed/NCBI | |
Cai CY, Zhai LL, Wu Y and Tang ZG: Expression and clinical value of peroxiredoxin-1 in patients with pancreatic cancer. Eur J Surg Oncol. 41:228–235. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kinnula VL, Lehtonen S, Sormunen R, Kaarteenaho-Wiik R, Kang SW, Rhee SG and Soini Y: Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesothelioma. J Pathol. 196:316–323. 2002. View Article : Google Scholar : PubMed/NCBI | |
Svendsen A, Verhoeff JJ, Immervoll H, Brøgger JC, Kmiecik J, Poli A, Netland IA, Prestegarden L, Planagumà J, Torsvik A, et al: Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathol. 122:495–510. 2011. View Article : Google Scholar : PubMed/NCBI | |
Riddell JR, Maier P, Sass SN, Moser MT, Foster BA and Gollnick SO: Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α. PLoS One. 7:e503942012. View Article : Google Scholar : PubMed/NCBI | |
Jiang H, Wu L, Mishra M, Chawsheen HA and Wei Q: Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy. Am J Cancer Res. 4:445–460. 2014.PubMed/NCBI | |
Ha B, Kim EK, Kim JH, Lee HN, Lee KO, Lee SY and Jang HH: Human peroxiredoxin 1 modulates TGF-β1-induced epithelial-mesenchymal transition through its peroxidase activity. Biochem Biophys Res Commun. 421:33–37. 2012. View Article : Google Scholar : PubMed/NCBI | |
Du ZX, Yan Y, Zhang HY, Liu BQ, Gao YY, Niu XF, Guan Y, Meng X and Wang HQ: Suppression of MG132-mediated cell death by peroxiredoxin 1 through influence on ASK1 activation in human thyroid cancer cells. Endocr Relat Cancer. 17:553–560. 2010. View Article : Google Scholar : PubMed/NCBI | |
Song IS, Kim SU, Oh NS, Kim J, Yu DY, Huang SM, Kim JM, Lee DS and Kim NS: Peroxiredoxin I contributes to TRAIL resistance through suppression of redox-sensitive caspase activation in human hepatoma cells. Carcinogenesis. 30:1106–1114. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yanagawa T, Ishikawa T, Ishii T, Tabuchi K, Iwasa S, Bannai S, Omura K, Suzuki H and Yoshida H: Peroxiredoxin I expression in human thyroid tumors. Cancer Lett. 145:127–132. 1999. View Article : Google Scholar : PubMed/NCBI | |
Nicolussi A, D'Inzeo S, Mincione G, Buffone A, Di Marcantonio MC, Cotellese R, Cichella A, Capalbo C, Di Gioia C, Nardi F, et al: PRDX1 and PRDX6 are repressed in papillary thyroid carcinomas via BRAF V600E-dependent and -independent mechanisms. Int J Oncol. 44:548–556. 2014.PubMed/NCBI | |
Wood ZA, Poole LB and Karplus PA: Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science. 300:650–653. 2003. View Article : Google Scholar : PubMed/NCBI | |
O'Neill JS and Reddy AB: Circadian clocks in human red blood cells. Nature. 469:498–503. 2011. View Article : Google Scholar : PubMed/NCBI | |
Cho CS, Yoon HJ, Kim JY, Woo HA and Rhee SG: Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells. Proc Natl Acad Sci USA. 111:12043–12048. 2014. View Article : Google Scholar : PubMed/NCBI | |
Avitabile D, Ranieri D, Nicolussi A, D'Inzeo S, Capriotti AL, Genovese L, Proietti S, Cucina A, Coppa A, Samperi R, et al: Peroxiredoxin 2 nuclear levels are regulated by circadian clock synchronization in human keratinocytes. Int J Biochem Cell Biol. 53:24–34. 2014. View Article : Google Scholar : PubMed/NCBI | |
Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN and Dick TP: Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol. 11:64–70. 2015. View Article : Google Scholar : PubMed/NCBI | |
Rhee SG and Woo HA: Multiple functions of peroxiredoxins: Peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones. Antioxid Redox Signal. 15:781–794. 2011. View Article : Google Scholar : PubMed/NCBI | |
Huo YY, Li G, Duan RF, Gou Q, Fu CL, Hu YC, Song BQ, Yang ZH, Wu DC and Zhou PK: PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts. Free Radic Biol Med. 44:1578–1591. 2008. View Article : Google Scholar : PubMed/NCBI | |
Barbosa AC, Funato N, Chapman S, McKee MD, Richardson JA, Olson EN and Yanagisawa H: Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol. 310:154–168. 2007. View Article : Google Scholar : PubMed/NCBI | |
Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K and Ushijima T: Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res. 66:6080–6086. 2006. View Article : Google Scholar : PubMed/NCBI | |
Lee DJ, Kang DH, Choi M, Choi YJ, Lee JY, Park JH, Park YJ, Lee KW and Kang SW: Peroxiredoxin-2 represses melanoma metastasis by increasing E-Cadherin/β-Catenin complexes in adherens junctions. Cancer Res. 73:4744–4757. 2013. View Article : Google Scholar : PubMed/NCBI | |
Feng J, Fu Z, Guo J, Lu W, Wen K, Chen W, Wang H, Wei J and Zhang S: Overexpression of peroxiredoxin 2 inhibits TGF-β1-induced epithelial-mesenchymal transition and cell migration in colorectal cancer. Mol Med Rep. 10:867–873. 2014.PubMed/NCBI | |
Pylväs M, Puistola U, Kauppila S, Soini Y and Karihtala P: Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis. Eur J Cancer. 46:1661–1667. 2010. View Article : Google Scholar : PubMed/NCBI | |
Hellman K, Alaiya AA, Becker S, Lomnytska M, Schedvins K, Steinberg W, Hellström AC, Andersson S, Hellman U and Auer G: Differential tissue-specific protein markers of vaginal carcinoma. Br J Cancer. 100:1303–1314. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kim K, Yu M, Han S, Oh I, Choi YJ, Kim S, Yoon K, Jung M and Choe W: Expression of human peroxiredoxin isoforms in response to cervical carcinogenesis. Oncol Rep. 21:1391–1396. 2009.PubMed/NCBI | |
Basu A, Banerjee H, Rojas H, Martinez SR, Roy S, Jia Z, Lilly MB, De León M and Casiano CA: Differential expression of peroxiredoxins in prostate cancer: Consistent upregulation of PRDX3 and PRDX4. Prostate. 71:755–765. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zhang B, Wang K, He G, Guan X, Liu B, Liu Y and Bai Y: Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer. J Cancer Res Clin Oncol. 138:621–626. 2012. View Article : Google Scholar : PubMed/NCBI | |
Trzeciecka A, Klossowski S, Bajor M, Zagozdzon R, Gaj P, Muchowicz A, Malinowska A, Czerwoniec A, Barankiewicz J, Domagala A, et al: Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. Oncotarget. 7:1717–1731. 2016.PubMed/NCBI | |
Stresing V, Baltziskueta E, Rubio N, Blanco J, Arriba MC, Valls J, Janier M, Clézardin P, Sanz-Pamplona R, Nieva C, et al: Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs. Oncogene. 32:724–735. 2013. View Article : Google Scholar : PubMed/NCBI | |
Lu W, Fu Z, Wang H, Feng J, Wei J and Guo J: Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress. Mol Cell Biochem. 387:261–270. 2014. View Article : Google Scholar : PubMed/NCBI | |
Watabe S, Hiroi T, Yamamoto Y, Fujioka Y, Hasegawa H, Yago N and Takahashi SY: SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria. Eur J Biochem. 249:52–60. 1997. View Article : Google Scholar : PubMed/NCBI | |
Miranda-Vizuete A, Damdimopoulos AE and Spyrou G: The mitochondrial thioredoxin system. Antioxid Redox Signal. 2:801–810. 2000. View Article : Google Scholar : PubMed/NCBI | |
Olmos Y, Sánchez-Gómez FJ, Wild B, García-Quintans N, Cabezudo S, Lamas S and Monsalve M: SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex. Antioxid Redox Signal. 19:1507–1521. 2013. View Article : Google Scholar : PubMed/NCBI | |
Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Bae KB, Park YH, Kim SU, Kim JM, Kim N, et al: FOXM1-Induced PRX3 regulates stemness and survival of colon cancer cells via maintenance of mitochondrial function. Gastroenterology. 149:1006–1016.e9. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li KK, Pang JC, Lau KM, Zhou L, Mao Y, Wang Y, Poon WS and Ng HK: MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). Brain Pathol. 23:413–425. 2013. View Article : Google Scholar : PubMed/NCBI | |
He HC, Zhu JG, Chen XB, Chen SM, Han ZD, Dai QS, Ling XH, Fu X, Lin ZY, Deng YH, et al: MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer. FEBS Lett. 586:2451–2458. 2012. View Article : Google Scholar : PubMed/NCBI | |
Xi H, Gao YH, Han DY, Li QY, Feng LJ, Zhang W, Ji G, Xiao JC, Zhang HZ and Wei Q: Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells. FEBS Lett. 588:3390–3394. 2014. View Article : Google Scholar : PubMed/NCBI | |
Choi JH, Kim TN, Kim S, Baek SH, Kim JH, Lee SR and Kim JR: Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. Anticancer Res. 22:3331–3335. 2002.PubMed/NCBI | |
Karihtala P, Mäntyniemi A, Kang SW, Kinnula VL and Soini Y: Peroxiredoxins in breast carcinoma. Clin Cancer Res. 9:3418–3424. 2003.PubMed/NCBI | |
Ummanni R, Barreto F, Venz S, Scharf C, Barett C, Mannsperger HA, Brase JC, Kuner R, Schlomm T, Sauter G, et al: Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro. J Proteome Res. 11:2452–2466. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kim YS, Lee HL, Lee KB, Park JH, Chung WY, Lee KS, Sheen SS, Park KJ and Hwang SC: Nuclear factor E2-related factor 2 dependent overexpression of sulfiredoxin and peroxiredoxin III in human lung cancer. Korean J Intern Med. 26:304–313. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hu JX, Gao Q and Li L: Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer. Biomed Rep. 1:228–230. 2013.PubMed/NCBI | |
Schulte J: Peroxiredoxin 4: A multifunctional biomarker worthy of further exploration. BMC Med. 9:1372011. View Article : Google Scholar : PubMed/NCBI | |
Okado-Matsumoto A, Matsumoto A, Fujii J and Taniguchi N: Peroxiredoxin IV is a secretable protein with heparin-binding properties under reduced conditions. J Biochem. 127:493–501. 2000. View Article : Google Scholar : PubMed/NCBI | |
Roumes H, Pires-Alves A, Gonthier-Maurin L, Dargelos E and Cottin P: Investigation of peroxiredoxin IV as a calpain-regulated pathway in cancer. Anticancer Res. 30:5085–5089. 2010.PubMed/NCBI | |
Ikeda Y, Nakano M, Ihara H, Ito R, Taniguchi N and Fujii J: Different consequences of reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4. J Biochem. 149:443–453. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zhu L, Yang K, Wang X, Wang X and Wang CC: A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. PLoS One. 9:e1055292014. View Article : Google Scholar : PubMed/NCBI | |
Ishii T, Warabi E and Yanagawa T: Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. J Clin Biochem Nutr. 50:91–105. 2012. View Article : Google Scholar : PubMed/NCBI | |
Mishra M, Jiang H, Wu L, Chawsheen HA and Wei Q: The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development. Cancer Lett. 366:150–159. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chen JH, Ni RZ, Xiao MB, Guo JG and Zhou JW: Comparative proteomic analysis of differentially expressed proteins in human pancreatic cancer tissue. Hepatobiliary Pancreat Dis Int. 8:193–200. 2009.PubMed/NCBI | |
Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, Sikes RA and Nelson PS: Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 69:1739–1747. 2009. View Article : Google Scholar : PubMed/NCBI | |
Chang KP, Yu JS, Chien KY, Lee CW, Liang Y, Liao CT, Yen TC, Lee LY, Huang LL, Liu SC, et al: Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology. J Proteome Res. 10:4935–4947. 2011. View Article : Google Scholar : PubMed/NCBI | |
Karihtala P, Kauppila S, Soini Y and Arja-Jukkola-Vuorinen: Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas. BMC Cancer. 11:2622011. View Article : Google Scholar : PubMed/NCBI | |
Karihtala P, Soini Y, Vaskivuo L, Bloigu R and Puistola U: DNA adduct 8-hydroxydeoxyguanosine, a novel putative marker of prognostic significance in ovarian carcinoma. Int J Gynecol Cancer. 19:1047–1051. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yi N, Xiao MB, Ni WK, Jiang F, Lu CH and Ni RZ: High expression of peroxiredoxin 4 affects the survival time of colorectal cancer patients, but is not an independent unfavorable prognostic factor. Mol Clin Oncol. 2:767–772. 2014.PubMed/NCBI | |
Wei Q, Jiang H, Xiao Z, Baker A, Young MR, Veenstra TD and Colburn NH: Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling. Proc Natl Acad Sci USA. 108:7004–7009. 2011. View Article : Google Scholar : PubMed/NCBI | |
Palande KK, Beekman R, van der Meeren LE, Beverloo HB, Valk PJ and Touw IP: The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia. PLoS One. 6:e163402011. View Article : Google Scholar : PubMed/NCBI | |
Knoops B, Goemaere J, Van der Eecken V and Declercq JP: Peroxiredoxin 5: Structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin. Antioxid Redox Signal. 15:817–829. 2011. View Article : Google Scholar : PubMed/NCBI | |
Nguyên-Nhu NT, Berck J, Clippe A, Duconseille E, Cherif H, Boone C, Van der Eecken V, Bernard A, Banmeyer I and Knoops B: Human peroxiredoxin 5 gene organization, initial characterization of its promoter and identification of alternative forms of mRNA. Biochim Biophys Acta. 1769:472–483. 2007. View Article : Google Scholar : PubMed/NCBI | |
Graves JA, Metukuri M, Scott D, Rothermund K and Prochownik EV: Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc. J Biol Chem. 284:6520–6529. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kropotov A, Usmanova N, Serikov V, Zhivotovsky B and Tomilin N: Mitochondrial targeting of human peroxiredoxin V protein and regulation of PRDX5 gene expression by nuclear transcription factors controlling biogenesis of mitochondria. FEBS J. 274:5804–5814. 2007. View Article : Google Scholar : PubMed/NCBI | |
Shiota M, Izumi H, Miyamoto N, Onitsuka T, Kashiwagi E, Kidani A, Hirano G, Takahashi M, Ono M, Kuwano M, et al: Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1. Cancer Sci. 99:1950–1959. 2008.PubMed/NCBI | |
Bur H, Haapasaari KM, Turpeenniemi-Hujanen T, Kuittinen O, Auvinen P, Marin K, Koivunen P, Sormunen R, Soini Y and Karihtala P: Oxidative stress markers and mitochondrial antioxidant enzyme expression are increased in aggressive Hodgkin lymphomas. Histopathology. 65:319–327. 2014. View Article : Google Scholar : PubMed/NCBI | |
Gérard AC, Many MC, Daumerie Ch, Knoops B and Colin IM: Peroxiredoxin 5 expression in the human thyroid gland. Thyroid. 15:205–209. 2005. View Article : Google Scholar : PubMed/NCBI | |
Fernandez-Ranvier GG, Weng J, Yeh RF, Shibru D, Khafnashar E, Chung KW, Hwang J, Duh QY, Clark OH and Kebebew E: Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13. World J Surg. 32:873–881. 2008. View Article : Google Scholar : PubMed/NCBI | |
Fisher AB: Peroxiredoxin 6: A bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. Antioxid Redox Signal. 15:831–844. 2011. View Article : Google Scholar : PubMed/NCBI | |
Choi HJ, Kang SW, Yang CH, Rhee SG and Ryu SE: Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Nat Struct Biol. 5:400–406. 1998. View Article : Google Scholar : PubMed/NCBI | |
Chowdhury I, Fisher AB, Christofidou-Solomidou M, Gao L, Tao JQ, Sorokina EM, Lien YC, Bates SR and Feinstein SI: Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic. Antioxid Redox Signal. 20:391–402. 2014. View Article : Google Scholar : PubMed/NCBI | |
Chowdhury I, Mo Y, Gao L, Kazi A, Fisher AB and Feinstein SI: Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. Free Radic Biol Med. 46:146–153. 2009. View Article : Google Scholar : PubMed/NCBI | |
Fatma N, Kubo E, Takamura Y, Ishihara K, Garcia C, Beebe DC and Singh DP: Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling. J Biol Chem. 284:22758–22772. 2009. View Article : Google Scholar : PubMed/NCBI | |
Chhunchha B, Fatma N, Bhargavan B, Kubo E, Kumar A and Singh DP: Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress. Cell Death Dis. 2:e2342011. View Article : Google Scholar : PubMed/NCBI | |
Wu X, Ji P, Zhang L, Bu G, Gu H, Wang X, Xiong Y and Zuo B: The expression of porcine Prdx6 gene is up-regulated by C/EBPβ and CREB. PLoS One. 10:e01448512015. View Article : Google Scholar : PubMed/NCBI | |
Power JH, Asad S, Chataway TK, Chegini F, Manavis J, Temlett JA, Jensen PH, Blumbergs PC and Gai WP: Peroxiredoxin 6 in human brain: Molecular forms, cellular distribution, and association with Alzheimer's disease pathology. Acta Neuropathol. 115:611–622. 2008. View Article : Google Scholar : PubMed/NCBI | |
Yun HM, Choi DY, Oh KW and Hong JT: PRDX6 exacerbates dopaminergic neurodegeneration in a MPTP mouse model of Parkinson's disease. Mol Neurobiol. 52:422–431. 2015. View Article : Google Scholar : PubMed/NCBI | |
El Eter E, Al Masri A, Habib S, Al Zamil H, Al Hersi A, Al Hussein F and Al Omran M: Novel links among peroxiredoxins, endothelial dysfunction, and severity of atherosclerosis in type 2 diabetic patients with peripheral atherosclerotic disease. Cell Stress Chaperones. 19:173–181. 2014. View Article : Google Scholar | |
Kubo E, Fatma N, Akagi Y, Beier DR, Singh SP and Singh DP: TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol. 294:C842–C855. 2008. View Article : Google Scholar : PubMed/NCBI | |
Thongwatchara P, Promwikorn W, Srisomsap C, Chokchaichamnankit D, Boonyaphiphat P and Thongsuksai P: Differential protein expression in primary breast cancer and matched axillary node metastasis. Oncol Rep. 26:185–191. 2011.PubMed/NCBI | |
Zhang J, Wang K, Zhang J, Liu SS, Dai L and Zhang JY: Using proteomic approach to identify tumor-associated proteins as biomarkers in human esophageal squamous cell carcinoma. J Proteome Res. 10:2863–2872. 2011. View Article : Google Scholar : PubMed/NCBI | |
Schremmer B, Manevich Y, Feinstein SI and Fisher AB: Peroxiredoxins in the lung with emphasis on peroxiredoxin VI. Subcell Biochem. 44:317–344. 2007. View Article : Google Scholar : PubMed/NCBI | |
Park JY, Kim SA, Chung JW, Bang S, Park SW, Paik YK and Song SY: Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer. J Cancer Res Clin Oncol. 137:1229–1238. 2011. View Article : Google Scholar : PubMed/NCBI | |
Shukla S, Pranay A, D'Cruz AK, Chaturvedi P, Kane SV and Zingde SM: Immunoproteomics reveals that cancer of the tongue and the gingivobuccal complex exhibit differential autoantibody response. Cancer Biomark. 5:127–135. 2009.PubMed/NCBI | |
Kuusisto ME, Haapasaari KM, Turpeenniemi-Hujanen T, Jantunen E, Soini Y, Peroja P, Bloigu R, Karihtala P and Kuittinen O: High intensity of cytoplasmic peroxiredoxin VI expression is associated with adverse outcome in diffuse large B-cell lymphoma independently of international prognostic index. J Clin Pathol. 68:552–556. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ and Shao ZM: Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer. Breast Cancer Res. 9:R762007. View Article : Google Scholar : PubMed/NCBI | |
Raatikainen S, Aaaltomaa S, Kärjä V and Soini Y: Increased peroxiredoxin 6 expression predicts biochemical recurrence in prostate cancer patients after radical prostatectomy. Anticancer Res. 35:6465–6470. 2015.PubMed/NCBI | |
Sofiadis A, Becker S, Hellman U, Hultin-Rosenberg L, Dinets A, Hulchiy M, Zedenius J, Wallin G, Foukakis T, Höög A, et al: Proteomic profiling of follicular and papillary thyroid tumors. Eur J Endocrinol. 166:657–667. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ho JN, Lee SB, Lee SS, Yoon SH, Kang GY, Hwang SG and Um HD: Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells. Mol Cancer Ther. 9:825–832. 2010. View Article : Google Scholar : PubMed/NCBI | |
Seibold P, Hall P, Schoof N, Nevanlinna H, Heikkinen T, Benner A, Liu J, Schmezer P, Popanda O, Flesch-Janys D and Chang-Claude J: Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients-potential differential effects by radiotherapy? Breast. 22:817–823. 2013. View Article : Google Scholar : PubMed/NCBI | |
Glasauer A and Chandel NS: Targeting antioxidants for cancer therapy. Biochem Pharmacol. 92:90–101. 2014. View Article : Google Scholar : PubMed/NCBI | |
Gorrini C, Harris IS and Mak TW: Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 12:931–947. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Karakhanova S, Werner J and Bazhin AV: Reactive oxygen species in cancer biology and anticancer therapy. Curr Med Chem. 20:3677–3692. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wang T, Diaz AJ and Yen Y: The role of peroxiredoxin II in chemoresistance of breast cancer cells. Breast Cancer (Dove Med Press). 6:73–80. 2014.PubMed/NCBI | |
Chung YM, Yoo YD, Park JK, Kim YT and Kim HJ: Increased expression of peroxiredoxin II confers resistance to cisplatin. Anticancer Res. 21:1129–1133. 2001.PubMed/NCBI | |
Kalinina EV, Berezov TT, Shtil AA, Chernov NN, Glazunova VA, Novichkova MD and Nurmuradov NK: Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation. Bull Exp Biol Med. 153:878–881. 2012.(In English, Russian). View Article : Google Scholar : PubMed/NCBI | |
Park SH, Chung YM, Lee YS, Kim HJ, Kim JS, Chae HZ and Yoo YD: Antisense of human peroxiredoxin II enhances radiation-induced cell death. Clin Cancer Res. 6:4915–4920. 2000.PubMed/NCBI | |
Pak JH, Choi WH, Lee HM, Joo WD, Kim JH, Kim YT, Kim YM and Nam JH: Peroxiredoxin 6 overexpression attenuates cisplatin-induced apoptosis in human ovarian cancer cells. Cancer Invest. 29:21–28. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kwon T, Rho JK, Lee JC, Park YH, Shin HJ, Cho S, Kang YK, Kim BY, Yoon DY and Yu DY: An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib. Exp Mol Med. 47:e1652015. View Article : Google Scholar : PubMed/NCBI | |
McDonald C, Muhlbauer J, Perlmutter G, Taparra K and Phelan SA: Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity. Int J Oncol. 45:219–226. 2014.PubMed/NCBI | |
Song IS, Kim HK, Jeong SH, Lee SR, Kim N, Rhee BD, Ko KS and Han J: Mitochondrial peroxiredoxin III is a potential target for cancer therapy. Int J Mol Sci. 12:7163–7185. 2011. View Article : Google Scholar : PubMed/NCBI | |
Li L and Yu AQ: The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells. J Cancer Res Clin Oncol. 141:2071–2077. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kropotov A, Gogvadze V, Shupliakov O, Tomilin N, Serikov VB, Tomilin NV and Zhivotovsky B: Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. Exp Cell Res. 312:2806–2815. 2006. View Article : Google Scholar : PubMed/NCBI | |
Butterfield LH, Merino A, Golub SH and Shau H: From cytoprotection to tumor suppression: The multifactorial role of peroxiredoxins. Antioxid Redox Signal. 1:385–402. 1999. View Article : Google Scholar : PubMed/NCBI | |
Neumann CA and Fang Q: Are peroxiredoxins tumor suppressors? Curr Opin Pharmacol. 7:375–380. 2007. View Article : Google Scholar : PubMed/NCBI | |
Woo HA, Jeong W, Chang TS, Park KJ, Park SJ, Yang JS and Rhee SG: Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins. J Biol Chem. 280:3125–3128. 2005. View Article : Google Scholar : PubMed/NCBI |