Invasive mucinous adenocarcinoma of the lung presenting as a large, thin-walled cyst: A case report and literature review

Masuzawa,Keita; Minematsu,Naoto; Sasaki,Mamoru; Ohsawa,Kazuma; Yamamoto,Tatsuya; Iwamaru,Arifumi; Ogata,Kentaro; Betsuyaku,Tomoko; Murakami,Marohito

doi:10.3892/mco.2017.1143

Invasive mucinous adenocarcinoma of the lung presenting as a large, thin-walled cyst: A case report and literature review

Authors:
- Keita Masuzawa
- Naoto Minematsu
- Mamoru Sasaki
- Kazuma Ohsawa
- Tatsuya Yamamoto
- Arifumi Iwamaru
- Kentaro Ogata
- Tomoko Betsuyaku
- Marohito Murakami
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Affiliations: Department of Medicine, Hino Municipal Hospital, Hino, Tokyo 191‑0062, Japan, Department of Surgery, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tachikawa, Tokyo 190‑8531, Japan, Division of Pathology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tachikawa, Tokyo 190‑8531, Japan, Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160‑8582, Japan
Published online on: January 31, 2017 https://doi.org/10.3892/mco.2017.1143
Pages: 433-437

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Abstract

Invasive mucinous adenocarcinoma (IMA), formerly referred to as mucinous bronchioloalveolar carcinoma, is a rare variant form of invasive adenocarcinoma and is radiologically characterized by dense pneumonic consolidation, ground‑glass opacity and nodules. By contrast, large, thin‑walled cysts are rare. We herein report the case of a 75‑year‑old man with IMA presenting as a large, irregularly shaped cystic lesion. The histological diagnosis was based on specimens obtained during a bronchoscopy. The patient underwent lobectomy followed by anticancer chemotherapy for residual intrapulmonary metastases. Of note, the small metastatic nodules transformed into cystic lesions with thin walls and fused, forming a large, multiloculated cystic lesion. Typical pneumonic consolidation appeared in the pericystic parenchyma later during the clinical course. The available literature on this rare radiological manifestation was also reviewed and discussed. Clinicians should be aware of thin‑walled cystic lesions as they may be an unusual radiological finding in IMA.

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