Open Access

Efficacy and safety of antitumor agents plus radiotherapy compared with radiotherapy alone for brain metastases from lung cancer

  • Authors:
    • Heng Lin
    • Shuimei Luo
    • Lina Li
    • Sijing Zhou
    • Ruifen Shen
    • Haitao Yang
    • Yupeng Wu
    • Xianhe Xie
  • View Affiliations

  • Published online on: February 3, 2017     https://doi.org/10.3892/mco.2017.1152
  • Pages: 296-306
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the efficacy and safety of different therapeutic regimens for brain metastases (BMs) from lung cancer (LC). A total of 13 controlled trials (1,783 cases) involving chemotherapy, tyrosine kinase inhibitors or endostatin plus radiotherapy (combination group) vs. radiotherapy alone group were identified from PubMed. Compared with the radiotherapy alone group, the combination group resulted in a significant benefit for objective response rate (ORR) [risk ratio (RR), 1.38; 95% confidence interval (CI), 1.19‑1.60; P<0.0001], notably prolonged the time to central nervous system progression [CNS‑TTP; hazard ratio (HR), 0.71; 95% CI, 0.57‑0.90; P=0.004] and progression‑free survival (PFS; HR, 0.60; 95% CI, 0.44‑0.83; P=0.002); however, failed in prolonging the overall survival (OS; HR, 0.80; 95% CI, 0.61‑1.05; P=0.11) with a higher overall severe adverse events (AEs, Grade ≥3; RR, 2.57; 95% CI, 1.24‑5.35; P=0.01). Notably, subgroup analysis demonstrated that targeted therapy plus radiotherapy possessed a superior OS compared with radiotherapy alone (HR, 0.58; 95% CI, 0.37‑0.90; P=0.01) with mild non‑hematological toxicity and without severe hematotoxicity. The present study demonstrated that targeted agents plus radiotherapy possessed desirable effects with mild adverse events. Secondary to best, chemoradiotherapy is an alternative option for patients without suitable molecular targets.
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March-2017
Volume 6 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Lin H, Luo S, Li L, Zhou S, Shen R, Yang H, Wu Y and Xie X: Efficacy and safety of antitumor agents plus radiotherapy compared with radiotherapy alone for brain metastases from lung cancer. Mol Clin Oncol 6: 296-306, 2017.
APA
Lin, H., Luo, S., Li, L., Zhou, S., Shen, R., Yang, H. ... Xie, X. (2017). Efficacy and safety of antitumor agents plus radiotherapy compared with radiotherapy alone for brain metastases from lung cancer. Molecular and Clinical Oncology, 6, 296-306. https://doi.org/10.3892/mco.2017.1152
MLA
Lin, H., Luo, S., Li, L., Zhou, S., Shen, R., Yang, H., Wu, Y., Xie, X."Efficacy and safety of antitumor agents plus radiotherapy compared with radiotherapy alone for brain metastases from lung cancer". Molecular and Clinical Oncology 6.3 (2017): 296-306.
Chicago
Lin, H., Luo, S., Li, L., Zhou, S., Shen, R., Yang, H., Wu, Y., Xie, X."Efficacy and safety of antitumor agents plus radiotherapy compared with radiotherapy alone for brain metastases from lung cancer". Molecular and Clinical Oncology 6, no. 3 (2017): 296-306. https://doi.org/10.3892/mco.2017.1152