Extranodal natural killer/T‑cell lymphoma presenting as cavernous sinus syndrome

Mai,Hong‑Cheng; Chen,Dan‑Xia; Lu,Dan; Zhang,Yu‑Sheng

doi:10.3892/mco.2017.1190

Extranodal natural killer/T‑cell lymphoma presenting as cavernous sinus syndrome

Authors:
- Hong‑Cheng Mai
- Dan‑Xia Chen
- Dan Lu
- Yu‑Sheng Zhang
View Affiliations

Affiliations: Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, P.R. China
Published online on: March 9, 2017 https://doi.org/10.3892/mco.2017.1190
Pages: 543-546

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Extranodal natural killer (NK)/T-cell lymphomas are rare, highly aggressive tumors of the central nervous system (CNS) that commonly affect the nasal cavity or paranasal sinuses. NK/T‑cell lymphomas are associated with a poor prognosis, as they exhibit a wide range of unique clinical presentations and neuroimaging findings that are currently difficult to detect. Pathological examination is considered to be more reliable for defining the pathological entity of NK/T‑cell lymphoma. Early testing for fluorodeoxyglucose (FDG)‑positron emission tomography combined with computed tomography may improve the evaluation of lymphomas, which have been known to display avid 18FDG uptake. The authors herein report a case of NK/T‑cell lymphoma presenting with cavernous sinus syndrome involving the CNS via direct extension from the nose. NK/T‑cell lymphomas are very aggressive, with an unfavorable clinical outcome, and the optimal therapy has not yet been clearly defined.

View Figures

View References

1	Liu JK, Sayama C, Chin SS and Couldwell WT: Extranodal NK/T-cell lymphoma presenting as a pituitary mass. Case report and review of the literature. J Neurosurg. 107:660–665. 2007. View Article : Google Scholar : PubMed/NCBI
2	Kwong YL: Natural killer-cell malignancies: Diagnosis and treatment. Leukemia. 19:2186–2194. 2005. View Article : Google Scholar : PubMed/NCBI
3	Khong PL, Pang CB, Liang R, Kwong YL and Au WY: Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies. Ann Hematol. 87:613–621. 2008. View Article : Google Scholar : PubMed/NCBI
4	Sitthinamsuwan P, Pongpruttipan T, Chularojmontri L, Pattanaprichakul P, Khuhapinant A and Sukpanichnant S: Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking granulomatous panniculitis: A case report and review of literature. J Med Assoc Thai. 93:1001–1007. 2010.PubMed/NCBI
5	Sun JC and Lanier LL: NK cell development, homeostasis and function: Parallels with CD8+ T cells. Nat Rev Immunol. 11:645–657. 2011. View Article : Google Scholar : PubMed/NCBI
6	Chen SM, Chang CN, Wei KC, Jung SM and Chuang CC: Sellar lymphoma mimicking sphenoid infection presenting with cavernous sinus syndrome. J Clin Neurosci. 15:1148–1151. 2008. View Article : Google Scholar : PubMed/NCBI
7	Keane JR: Cavernous sinus syndrome. Analysis of 151 cases. Arch Neurol. 53:967–971. 1996. View Article : Google Scholar : PubMed/NCBI
8	Jahnke K, Thiel E, Martus P, Schwartz S and Korfel A: Retrospective study of prognostic factors in non-Hodgkin lymphoma secondarily involving the central nervous system. Ann Hematol. 85:45–50. 2006. View Article : Google Scholar : PubMed/NCBI
9	Li Z, Xia Y, Feng LN, Chen JR, Li HM, Cui J, Cai QQ, Sim KS, Nairismägi ML, Laurensia Y, et al: Genetic risk of extranodal natural killer T-cell lymphoma: A genome-wide association study. Lancet Oncol. 17:1240–1247. 2016. View Article : Google Scholar : PubMed/NCBI
10	Kwong YL, Kim WS, Lim ST, Kim SJ, Tang T, Tse E, Leung AY and Chim CS: SMILE for natural killer/T-cell lymphoma: Analysis of safety and efficacy from the Asia lymphoma study group. Blood. 120:2973–2980. 2012. View Article : Google Scholar : PubMed/NCBI
11	Chan JK, Tsang WY and Ng CS: Clarification of CD3 immunoreactivity in nasal T/natural killer cell lymphomas: The neoplastic cells are often CD3 epsilon+. Blood. 87:839–841. 1996.PubMed/NCBI
12	Sabattini E, Bacci F, Sagramoso C and Pileri SA: WHO classification of tumours of haematopoietic and lymphoid tissues in 2008 An overview. Pathologica. 102:83–87. 2010.PubMed/NCBI
13	Kasenda B, Haug V, Schorb E, Fritsch K, Finke J, Mix M, Hader C, Weber WA, Illerhaus G and Meyer PT: 18F-FDG PET is an independent outcome predictor in primary central nervous system lymphoma. J Nucl Med. 54:184–191. 2013. View Article : Google Scholar : PubMed/NCBI
14	Tse E and Kwong YL: How I treat NK/T-cell lymphomas. Blood. 121:4997–5005. 2013. View Article : Google Scholar : PubMed/NCBI
15	Lee J, Suh C, Park YH, Ko YH, Bang SM, Lee JH, Lee DH, Huh J, Oh SY, Kwon HC, et al: Extranodal natural killer T-cell lymphoma, nasal-type: A prognostic model from a retrospective multicenter study. J Clin Oncol. 24:612–618. 2006. View Article : Google Scholar : PubMed/NCBI