Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma

  • Authors:
    • Yakup Bozkaya
    • Nebi̇ Serkan Demi̇rci
    • Ali̇can Kurti̇pek
    • Gökmen   Umut Erdem
    • Nuri̇ye Yildirim Ozdemi̇r
    • Nurullah Zengi̇
  • View Affiliations

  • Published online on: June 8, 2017     https://doi.org/10.3892/mco.2017.1288
  • Pages: 267-274
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Abstract

The aim of the present study was to determine whether there are any clinicopathological or prognostic differences between patients with α-fetoprotein-secreting gastric carcinoma (AFP-SGC) and non-AFP-SGC. Pathological parameters, clinical parameters, and treatment efficacy were compared in patients with AFP-SGC and non-AFP-SGC. In total, 362 patients (53 with AFP-SGC and 309 with non-AFP-SGC) were included in the present study. Patients with AFP-SGC had significantly higher levels of lymphovascular invasion, perineural invasion (PNI), rate of liver metastasis, and stage IV cancer compared with patients with non-AFP-SGC (P<0.05). The median overall survival (OS) rate was 12.6 months in the AFP-SGC group, and 22.1 months in the non-AFP-SGC group (P<0.001). The median OS and disease free survival (DFS) of patients with stage I-III AFP-SGC were 28.1 and 13.4 months, respectively, whereas for patients with non-AFP-SGC, the OS and DFS were 45.3 and 38.0 months, respectively (P=0.01; P=0.02). The median OS for the stage IV AFP-SGC and non-AFP-SGC groups was 9.3 and 11.5 months, respectively (P=0.14). Multivariate analysis of the entire patient group revealed that the Eastern Cooperative Oncology Group (ECOG) performance score of ≥2, lymph node involvement, presence of PNI, high levels of carcinoembryonic antigen, and distant metastasis were significantly correlated with OS. The lymph node involvement, ECOG performance score of ≥2, AFP-SGC type, and weight loss at diagnosis were also significant factors influencing the DFS in the stage I-III group. In conclusion, patients with AFP-SGC had more aggressive clinicopathological features and biological behavior with an increased tendency of liver metastasis compared with patients with non-AFP-SGC. In the near future, AFP may become an important surrogate marker to manage therapies of patients with gastric cancer.
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August-2017
Volume 7 Issue 2

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Spandidos Publications style
Bozkaya Y, Demi̇rci NS, Kurti̇pek A, Erdem GU, Ozdemi̇r NY and Zengi̇ N: Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma. Mol Clin Oncol 7: 267-274, 2017
APA
Bozkaya, Y., Demi̇rci, N.S., Kurti̇pek, A., Erdem, G.U., Ozdemi̇r, N.Y., & Zengi̇, N. (2017). Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma. Molecular and Clinical Oncology, 7, 267-274. https://doi.org/10.3892/mco.2017.1288
MLA
Bozkaya, Y., Demi̇rci, N. S., Kurti̇pek, A., Erdem, G. U., Ozdemi̇r, N. Y., Zengi̇, N."Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma". Molecular and Clinical Oncology 7.2 (2017): 267-274.
Chicago
Bozkaya, Y., Demi̇rci, N. S., Kurti̇pek, A., Erdem, G. U., Ozdemi̇r, N. Y., Zengi̇, N."Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma". Molecular and Clinical Oncology 7, no. 2 (2017): 267-274. https://doi.org/10.3892/mco.2017.1288