Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Wang,Hongli; Liu,Fengtao; Gu,Ran; Li,Yong; Su,Fengxi

doi:10.3892/mco.2017.1322

Rare imaging appearance of adenoid cystic carcinoma of the breast: A case report

Authors:
- Hongli Wang
- Fengtao Liu
- Ran Gu
- Yong Li
- Fengxi Su
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Affiliations: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China
Published online on: July 13, 2017 https://doi.org/10.3892/mco.2017.1322
Pages: 473-475

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Abstract

Adenoid cystic carcinoma (ACC) of the breast is a rare tumor comprising <0.1% of all breast malignancies. The present study reports the case of a 66‑year‑old woman who underwent multiple imaging techniques, including mammography, ultrasonography and magnetic resonance imaging (MRI). The patient reported gradual enlargement of a mass in the left breast. Mammography identified a high‑density, irregular mass, with nipple retraction. Ultrasonography revealed an irregular, complex cystic and solid mass with an unclear margin in the subareolar region. The internal vascularity was seen on Doppler examination. The lesion on MRI was also mixed cystic and solid, with an irregular shape and irregular margins. The solid part of the lesion appeared heterogeneously isointense on T1‑weighted imaging (WI) and a slightly high signal on T2WI, and exhibited internal septations with a low signal on T2WI. Following injection of contrast agent, the enhancement of the solid part was rapid and heterogeneous. The cystic parts of lesion appeared as high‑signal on T1WI and T2WI. The tumor infiltrated the left nipple and adjacent skin. The patient underwent a left modified radical mastectomy with axillary lymph node dissection. The pathological examination confirmed the tumor as ACC of the left breast. The axillary lymph nodes were negative for tumor metastasis. Therefore, the differential diagnosis of mixed cystic and solid breast masses with unclear margins and internal septations on T2WI exhibiting delayed enhancement, must include ACC.

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1	Cavanzo FJ and Taylor HB: Adenoid cystic carcinoma of the breast. An analysis of 21 cases. Cancer. 24:740–745. 1969. View Article : Google Scholar : PubMed/NCBI
2	Cleveland RH, Nice CM Jr and Ziskind J: Primary adenoid cystic carcinoma (cylindroma) of the trachea. Radiology. 122:597–600. 1977. View Article : Google Scholar : PubMed/NCBI
3	Prempree T, Villasanta U and Tang CK: Management of adenoid cystic carcinoma of the uterine cervix (cylindroma): Report of six cases and reappraisal of all cases reported in the medical literature. Cancer. 46:1631–1635. 1980. View Article : Google Scholar : PubMed/NCBI
4	Olofsson J and van Nostrand AW: Adenoid cystic carcinoma of the larynx: A report of four cases and a review of the literature. Cancer. 40:1307–1313. 1977. View Article : Google Scholar : PubMed/NCBI
5	Addison A and Parker RT: Adenoid cystic carcinoma of Bartholin's gland: A review of the literature and report of a patient. Gynecol Oncol. 5:196–201. 1977. View Article : Google Scholar : PubMed/NCBI
6	Boujelbene N, Khabir A, Boujelbene N, Sozzi W Jeanneret, Mirimanoff RO and Khanfir K: Clinical review-breast adenoid cystic carcinoma. Breast. 21:124–127. 2012. View Article : Google Scholar : PubMed/NCBI
7	Tang W, Peng WJ, Gu YJ, Zhu H, Jiang TT and Li C: Imaging manifestation of adenoid cystic carcinoma of the breast. J Comput Assist Tomogr. 39:523–530. 2015. View Article : Google Scholar : PubMed/NCBI
8	Glazebrook KN, Reynolds C, Smith RL, Gimenez EI and Boughey JC: Adenoid cystic carcinoma of the breast. AJR Am J Roentgenol. 194:1391–1396. 2010. View Article : Google Scholar : PubMed/NCBI
9	Billroth T: Studies on the Development of the Blood Vessels Combined with Observations from the Royal Surgical University Clinic of Berlin. Georg Reimer, Berlin. 55–69. 1856.(In German).
10	Geschickter CF and Copeland MM: Diseases of the Breast: Diagnosis, Pathology, Treatment. 2nd. J B Lippincott; Philadelphia: pp. 421–422. 1945
11	Ghabach B, Anderson WF, Curtis RE, Huycke MM, Lavigne JA and Dores GM: Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): A population-based cohort study. Breast Cancer Res. 12:R542010. View Article : Google Scholar : PubMed/NCBI
12	Da Silva L, Buck L, Simpson PT, Reid L, McCallum N, Madigan BJ and Lakhani SR: Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. Virchows Arch. 454:107–114. 2009. View Article : Google Scholar : PubMed/NCBI
13	Arpino G, Clark GM, Mohsin S, Bardou VJ and Elledge RM: Adenoid cystic carcinoma of the breast: Molecular markers, treatment, and clinical outcome. Cancer. 94:2119–2127. 2002. View Article : Google Scholar : PubMed/NCBI
14	Mastropasqua MG, Maiorano E, Pruneri G, Orvieto E, Mazzarol G, Vento AR and Viale G: Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. Mod Pathol. 18:1277–1282. 2005. View Article : Google Scholar : PubMed/NCBI
15	Peters GN and Wolff M: Adenoid cystic carcinoma of the breast. Report of 11 new cases: Review of the literature and discussion of biological behavior. Cancer. 52:680–686. 1983. View Article : Google Scholar : PubMed/NCBI
16	Youk JH, Kim MJ, Kim EK, Lee JY, Oh KK and Park BW: Recurrence of adenoid cystic carcinoma in the breast after lumpectomy and adjuvant therapy. J Ultrasound Med. 25:921–924. 2006. View Article : Google Scholar : PubMed/NCBI
17	Ichikawa K, Mizukami Y, Takayama T, Takemura A, Miyati T and Taniya T: A case of adenoid cystic carcinoma of the breast. J Med Ultrason (2001). 34:193–196. 2007. View Article : Google Scholar : PubMed/NCBI
18	de Luis E, Apesteguía L, Noguera JJ, Pina L, Martínez-Regueira F, Miguel C and Sáenz J: Adenoid cystic carcinoma of the breast. Radiologia. 48:235–240. 2006.(In Spanish). View Article : Google Scholar : PubMed/NCBI
19	Santamaría G, Velasco M, Zanón G, Farrús B, Molina R, Solé M and Fernández PL: Adenoid cystic carcinoma of the breast: Mammographic appearance and pathologic correlation. AJR Am J Roentgenol. 171:1679–1683. 1998. View Article : Google Scholar : PubMed/NCBI
20	Tsuboi N, Ogawa Y, Inomata T, Nishioka A, Yoshida D, Yoshida S and Moriki T: Dynamic MR appearance of adenoid cystic carcinoma of the breast in a 67-year-old female. Radiat Med. 16:225–228. 1998.PubMed/NCBI