Open Access

The optimum marker for the detection of lymphatic vessels (Review)

  • Authors:
    • Ling‑Ling Kong
    • Nian‑Zhao Yang
    • Liang‑Hui Shi
    • Guo‑Hai Zhao
    • Wenbin Zhou
    • Qiang Ding
    • Ming‑Hai Wang
    • Yi‑Sheng Zhang
  • View Affiliations

  • Published online on: July 31, 2017     https://doi.org/10.3892/mco.2017.1356
  • Pages: 515-520
  • Copyright: © Kong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Podoplanin, lymphatic vessel endothelial hyaluronic acid receptor-1, prospero-related homeobox-1 and vascular endothelial growth factor receptor 3 have been demonstrated to have crucial roles in the development of the lymphatic system and lymphangiogenesis process by combining with their corresponding receptors. Thus, the four markers have been widely used in labelling lymphatic vessels for the detection of lymphangiogenesis and lymphatic vessel invasion. Numerous authors have aimed to identify the roles of these four markers in the lymphatic system and the mechanisms have been partly clarified at the molecular level. The aim of the present review was to comprehensively clarify the characteristics and latent action modes of the four markers in order to determine which is the best one for the detection of lymphangiogenesis and lymphatic vessel invasion.
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October-2017
Volume 7 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Kong LL, Yang NZ, Shi LH, Zhao GH, Zhou W, Ding Q, Wang MH and Zhang YS: The optimum marker for the detection of lymphatic vessels (Review). Mol Clin Oncol 7: 515-520, 2017
APA
Kong, L., Yang, N., Shi, L., Zhao, G., Zhou, W., Ding, Q. ... Zhang, Y. (2017). The optimum marker for the detection of lymphatic vessels (Review). Molecular and Clinical Oncology, 7, 515-520. https://doi.org/10.3892/mco.2017.1356
MLA
Kong, L., Yang, N., Shi, L., Zhao, G., Zhou, W., Ding, Q., Wang, M., Zhang, Y."The optimum marker for the detection of lymphatic vessels (Review)". Molecular and Clinical Oncology 7.4 (2017): 515-520.
Chicago
Kong, L., Yang, N., Shi, L., Zhao, G., Zhou, W., Ding, Q., Wang, M., Zhang, Y."The optimum marker for the detection of lymphatic vessels (Review)". Molecular and Clinical Oncology 7, no. 4 (2017): 515-520. https://doi.org/10.3892/mco.2017.1356