Primary malignant lymphoma of the talus: A case report and review of the literature

Sato,Shunsuke; Kaneuchi,Yoichi; Hakozaki,Michiyuki; Yamada,Hitoshi; Kawana,Satoshi; Hasegawa,Osamu; Konno,Shinichi

doi:10.3892/mco.2017.1362

Primary malignant lymphoma of the talus: A case report and review of the literature

Authors:
- Shunsuke Sato
- Yoichi Kaneuchi
- Michiyuki Hakozaki
- Hitoshi Yamada
- Satoshi Kawana
- Osamu Hasegawa
- Shinichi Konno
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Affiliations: Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan, Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan, Department of Radiology, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan
Published online on: August 3, 2017 https://doi.org/10.3892/mco.2017.1362
Pages: 574-578
Copyright: © Sato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Malignant lymphoma commonly occurs in adults, with a peak incidence between the seventh and ninth decades of life. Although malignant lymphoma usually occurs in the lymph nodes, it rarely occurs primarily in the bone. We herein describe an extremely rare case of primary malignant lymphoma of the talus in a 74‑year‑old man. Although plain radiographs showed no abnormality, gadolinium‑enhanced magnetic resonance imaging (MRI) revealed a well‑circumscribed intra‑ and extraosseous tumor of the talus. 18F‑fluorodeoxyglucose (FDG) positron emission tomography/MRI revealed a marked increase of FDG uptake in the right ankle and the right inguinal lymph nodes. As the tumor was diagnosed as diffuse large B‑cell lymphoma by core needle biopsy, combination therapy with chemo‑ and radiotherapy was initiated. The patient achieved complete remission, with no sign of recurrence at 8 months after initial chemoradiotherapy. Since primary malignant lymphoma of the bone is chemo‑ and radiosensitive and has a good prognosis, accurate staging by radiological investigation as well as correct pathological diagnosis by biopsy are required for optimal treatment.

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