Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report

  • Authors:
    • Kaname Sakuma
    • Ryuki Tamura
    • Naoto Noda
    • Masutaka Mizutani
    • Akira Yamaguchi
    • Akira Tanaka
  • View Affiliations

  • Published online on: August 8, 2017     https://doi.org/10.3892/mco.2017.1367
  • Pages: 637-641
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Abstract

In vitro anticancer drug sensitivity assessments have been performed for various types of cancer, and an association with clinical response has been observed. The collagen gel droplet‑embedded culture drug sensitivity test (CD‑DST) is an in vitro anticancer drug sensitivity test that has recently reported to be useful in oral squamous cell carcinoma (OSCC). CD‑DST allows for the analysis of a smaller number of cells compared with other anticancer drug sensitivity tests. The present study reported a successful analysis of anticancer drug sensitivity using CD‑DST on cervical lymph node tissue dissected following neoadjuvant chemotherapy from a 55‑year‑old man with advanced hard palate cancer. Tumor resection and bilateral neck dissection were performed following neoadjuvant chemotherapy (docetaxel + cisplatin + 5‑fluorouracil; TPF) for hard palate cancer T2N2cM0. Local recurrence and cervical multiple skin metastasis occurred ~8 months after surgery, and the patient received six doses of cetuximab (C‑mab) + cisplatin + 5‑fluorouracil (C‑mab + PF) administration, which is a type of molecular‑targeted therapy. Following the use of the CD‑DST method, the clinical response was noted as stable disease following execution of TPF and partial response following execution of C‑mab + PF. In addition, low sensitivity by TPF and high sensitivity by C‑mab + PF were reported. The CD‑DST method reflected the clinical response for the patient, and the results of the current study indicate that CD‑DST is a useful tool for selecting chemotherapeutic drugs for patients with OSCC.
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October-2017
Volume 7 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Sakuma K, Tamura R, Noda N, Mizutani M, Yamaguchi A and Tanaka A: Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report. Mol Clin Oncol 7: 637-641, 2017
APA
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., & Tanaka, A. (2017). Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report. Molecular and Clinical Oncology, 7, 637-641. https://doi.org/10.3892/mco.2017.1367
MLA
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., Tanaka, A."Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report". Molecular and Clinical Oncology 7.4 (2017): 637-641.
Chicago
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., Tanaka, A."Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report". Molecular and Clinical Oncology 7, no. 4 (2017): 637-641. https://doi.org/10.3892/mco.2017.1367