Rapid occurrence of left ventricular thrombus associated with platinum‑based chemotherapy plus cetuximab for the treatment of metastatic squamous cell carcinoma of the head and neck: A case report

Ikeda,Atsushi; Yamachika,Eiki; Mizutani,Masahide; Matsubara,Masakazu; Moritani,Norifumi; Nakatsuji,Kazuki; Iida,Seiji

doi:10.3892/mco.2017.1393

Rapid occurrence of left ventricular thrombus associated with platinum‑based chemotherapy plus cetuximab for the treatment of metastatic squamous cell carcinoma of the head and neck: A case report

Authors:
- Atsushi Ikeda
- Eiki Yamachika
- Masahide Mizutani
- Masakazu Matsubara
- Norifumi Moritani
- Kazuki Nakatsuji
- Seiji Iida
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Affiliations: Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital, Okayama, Okayama 700‑8558, Japan, Department of Dentistry, Oral and Maxillofacial Surgery, Osaka Police Hospital, Osaka, Osaka 543‑0035, Japan
Published online on: August 25, 2017 https://doi.org/10.3892/mco.2017.1393
Pages: 833-836

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Abstract

Platinum‑based chemotherapy plus cetuximab represents the first‑line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck. The most common adverse events associated with cetuximab are infusion reactions and skin reactions, and a risk of venous thromboembolic events has also recently been reported in association with cetuximab. It is well known that thrombosis is a common complication of malignancy, and represents the second most frequent cause of mortality in cancer patients. The present study reports the case of a 79‑year‑old man who presented with lung and liver metastases from tongue squamous cell carcinoma, for which platinum‑based chemotherapy plus cetuximab was administered. After 1 cycle, the patient showed rapid growth of a left ventricular (LV) thrombus, despite ongoing antiplatelet therapy for an old myocardial infarction. Anticoagulant therapy was administered to treat the LV thrombus, which resolved within 1 week. To the best of our knowledge, this represents the first reported case of rapidly occurring LV thrombus associated with platinum‑based chemotherapy plus cetuximab. Platinum‑based chemotherapy plus cetuximab may be associated with a higher risk of embolic thrombus.

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