Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy

Yang,Qingxi; Ji,Guangdong; Pan,Rongtao; Zhao,Yinghui; Yan,Peng

doi:10.3892/mco.2017.1409

Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy

Authors:
- Qingxi Yang
- Guangdong Ji
- Rongtao Pan
- Yinghui Zhao
- Peng Yan
View Affiliations

Affiliations: Department of Oncology, Shandong Provincial Taishan Hospital, Taian, Shandong 271000, P.R. China, Department of Pathology, Taishan Medical University, Taian, Shandong 271000, P.R. China, Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China
Published online on: September 1, 2017 https://doi.org/10.3892/mco.2017.1409
Pages: 891-896

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The present study was conducted to investigate the protective effect of hydrogen‑rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single‑blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February 2016, among whom 146 met the inclusion criteria. Subsequently, 144 patients were randomized into the treatment (n=80) and placebo (n=64) groups. At the end of the study, 76 patients in the hydrogen treatment group and 60 patients in the placebo group were included in the final analysis. The changes in liver function after the chemotherapy, such as altered levels of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase, indirect bilirubin (IBIL) and direct bilirubin, were observed. The damaging effects of the mFOLFOX6 chemotherapy on liver function were mainly represented by increased ALT, AST and IBIL levels. The hydrogen‑rich water group exhibited no significant differences in liver function before and after treatment, whereas the placebo group exhibited significantly elevated levels of ALT, AST and IBIL. Thus, hydrogen‑rich water appeared to alleviate the mFOLFOX6‑related liver injury.

View Figures

View References

1	Christova TY, Gorneva GA, Taxirov SI, Duridanova DB and Setchenska MS: Effect of cisplatin and cobalt chloride on antioxidant enzymes in the livers of Lewis lung carcinoma bearing mice: Protective role of heme oxygenase. Toxicol Lett. 138:235–242. 2003. View Article : Google Scholar : PubMed/NCBI
2	Koc A, Duru M, Ciralik H, Akcan R and Sogut S: Protective agent, erdosteine, against cisplatin-induced hepatic oxidant injury in rats. Mol Cell Biochem. 278:79–84. 2005. View Article : Google Scholar : PubMed/NCBI
3	Robinson K, Lambiase L, Li J, Monteiro C and Schiff M: Fatal cholestatic liver failure associated with gemcitabine therapy. Dig Dis Sci. 48:1804–1808. 2003. View Article : Google Scholar : PubMed/NCBI
4	Bibeau F, Azria D, Chateau MC, Borrelly C, Ychou M, Quenet F and Rouanet P: Vascular hepatic injury following neoadjuvant treatment for a cardial adenocarcinoma. Gastroenterol Clin Biol. 30:611–613. 2006.(In French). View Article : Google Scholar : PubMed/NCBI
5	Huang CS, Kawamura T, Toyoda Y and Nakao A: Recent advances in hydrogen research as a therapeutic medical gas. Free Radic Res. 44:971–282. 2010. View Article : Google Scholar : PubMed/NCBI
6	Cardinal JS, Zhan J, Wang Y, Sugimoto R, Tsung A, McCurry KR, Billiar TR and Nakao A: Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney Int. 77:101–109. 2010. View Article : Google Scholar : PubMed/NCBI
7	Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L and Sun XJ: Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun. 381:602–605. 2009. View Article : Google Scholar : PubMed/NCBI
8	National Comprehensive Cancer Network: (NCCN) Clinical Practice Guidelines in Oncology. Colon Cancer. Version 1. 2012 https://www.nccn.org/professionals/physician_gls/f_guidelines.aspAccessed. August 30–2011.
9	Fong Y and Bentrem DJ: CASH (chemotherapy-associated steatohepatitis) costs. Ann Surg. 243:8–9. 2006. View Article : Google Scholar : PubMed/NCBI
10	Maor Y and Malnick S: Liver injury induced by anticancer chemotherapy and radiation therapy. Int J Hepatol. 2013:8151052013. View Article : Google Scholar : PubMed/NCBI
11	Pawlik TM, Olino K, Gleisner AL, Torbenson M, Schulick R and Choti MA: Preoperative chemotherapy for colorectal liver metastases: Impact on hepatic histology and postoperative outcome. J Gastrointest Surg. 11:860–868. 2007. View Article : Google Scholar : PubMed/NCBI
12	Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, Xiong HQ, Eng C, Lauwers GY, Mino-Kenudson M, et al: Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol. 24:2065–2072. 2006. View Article : Google Scholar : PubMed/NCBI
13	Tamandl D, Klinger M, Eipeldauer S, Herberger B, Kaczirek K, Gruenberger B and Gruenberger T: Sinusoidal obstruction syndrome impairs long-term outcome of colorectal liver metastases treated with resection after neoadjuvant chemotherapy. Ann Surg Oncol. 18:421–430. 2011. View Article : Google Scholar : PubMed/NCBI
14	Laurent A, Nicco C, Van Nhieu Tran J, Borderie D, Chéreau C, Conti F, Jaffray P, Soubrane O, Calmus Y, Weill B and Batteux F: Pivotal role of superoxide anion and beneficial effect of antioxidant molecules in murine steatohepatitis. Hepatology. 39:1277–1285. 2004. View Article : Google Scholar : PubMed/NCBI
15	Pessayre D, Berson A, Fromenty B and Mansouri A: Mitochondria in steatohepatitis. Semin Liver Dis. 21:57–69. 2001. View Article : Google Scholar : PubMed/NCBI
16	Rubbia-Brandt L, Audard V, Sartoretti P, Roth AD, Brezault C, Le Charpentier M, Dousset B, Morel P, Soubrane O, Chaussade S, et al: Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Ann Oncol. 15:460–466. 2004. View Article : Google Scholar : PubMed/NCBI
17	Nakano H, Oussoultzoglou E, Rosso E, Casnedi S, Chenard-Neu MP, Dufour P, Bachellier P and Jaeck D: Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg. 247:118–124. 2008. View Article : Google Scholar : PubMed/NCBI
18	Dyson JK, McPherson S and Anstee QM: Non-alcoholic fatty liver disease: Non-invasive investigation and risk stratification. J Clin Pathol. 66:1033–1045. 2013. View Article : Google Scholar : PubMed/NCBI
19	Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S and Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 13:688–694. 2007. View Article : Google Scholar : PubMed/NCBI
20	Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, et al: Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun. 373:30–35. 2008. View Article : Google Scholar : PubMed/NCBI
21	Buchholz BM, Kaczorowski DJ, Sugimoto R, Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ and Nakao A: Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant. 8:2015–2024. 2008. View Article : Google Scholar : PubMed/NCBI
22	Sun Q, Kang Z, Cai J, Liu W, Liu Y, Zhang JH, Denoble PJ, Tao H and Sun X: Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Exp Biol Med (Maywood). 234:1212–1219. 2009. View Article : Google Scholar : PubMed/NCBI
23	Fukuda K, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I and Ohta SP: Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun. 361:670–674. 2007. View Article : Google Scholar : PubMed/NCBI
24	Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H and Li R: Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett. 441:167–172. 2008. View Article : Google Scholar : PubMed/NCBI
25	Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, et al: Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett. 453:81–85. 2009. View Article : Google Scholar : PubMed/NCBI
26	Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S and Ohta S: Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol. 64:753–761. 2009. View Article : Google Scholar : PubMed/NCBI
27	Liu Y, Yang L, Tao K, Vizcaychipi MP, Lloyd DM, Sun X, Irwin MG, Ma D and Yu W: Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol. 14:122014. View Article : Google Scholar : PubMed/NCBI
28	Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM and Sun XJ: Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver Int. 30:958–968. 2010. View Article : Google Scholar : PubMed/NCBI
29	Xu XF and Zhang J: Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res. 62:395–403. 2013.PubMed/NCBI
30	Levitt MD and Bond JH Jr: Volume, composition, and source of intestinal gas. Gastroenterology. 59:921–929. 1970.PubMed/NCBI