Open Access

High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma

  • Authors:
    • Kohei Nakamura
    • Kentaro Nakayama
    • Toshiko Minamoto
    • Tomoka Ishibashi
    • Kaori Sanuki
    • Hitomi Yamashita
    • Ruriko Ono
    • Hiroki Sasamori
    • Takayoshi Komatsu‑Fujii
    • Masako Ishikawa
    • Satoru Kyo
  • View Affiliations

  • Published online on: January 10, 2018     https://doi.org/10.3892/mco.2018.1551
  • Pages: 429-433
  • Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to determine the prognostic value of the Glasgow prognostic score (GPS) in endometrial carcinoma (EC). Patients with EC who underwent surgery at the Shimane University Hospital between January 1997 and December 2013 were enrolled (n=118). The associations between pretreatment GPS and clinical parameters, including age, histological type, International Federation of Gynecology and Obstetrics stage, tumor grade, carbohydrate antigen 19‑9 and carcinoembryonic antigen levels, progression‑free survival (PFS), and overall survival (OS), were investigated. Survival analysis was performed with the Kaplan‑Meier method, and prognostic factors were evaluated with Cox's proportional hazards regression model. A high pretreatment GPS was associated with advanced clinical stage, histological type and tumor grade (P<0.001, P=0.007 and P=0.006, respectively). Multivariate analysis identified a high GPS as an independent negative prognostic factor for PFS and OS (P=0.025 and P=0.044, respectively). Therefore, a high pretreatment GPS has prognostic value and the potential to be a predictive marker for surgical outcome in patients with EC. Evaluation of pretreatment GPS may aid in the identification of high‑risk populations, which may improve treatment selection and patient outcomes.
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March-2018
Volume 8 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Nakamura K, Nakayama K, Minamoto T, Ishibashi T, Sanuki K, Yamashita H, Ono R, Sasamori H, Komatsu‑Fujii T, Ishikawa M, Ishikawa M, et al: High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma. Mol Clin Oncol 8: 429-433, 2018
APA
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H. ... Kyo, S. (2018). High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma. Molecular and Clinical Oncology, 8, 429-433. https://doi.org/10.3892/mco.2018.1551
MLA
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H., Ono, R., Sasamori, H., Komatsu‑Fujii, T., Ishikawa, M., Kyo, S."High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma". Molecular and Clinical Oncology 8.3 (2018): 429-433.
Chicago
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H., Ono, R., Sasamori, H., Komatsu‑Fujii, T., Ishikawa, M., Kyo, S."High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma". Molecular and Clinical Oncology 8, no. 3 (2018): 429-433. https://doi.org/10.3892/mco.2018.1551