Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery

Makino,Takashi; Otsuka,Hajime; Hata,Yoshinobu; Koezuka,Satoshi; Azuma,Yoko; Isobe,Kazutoshi; Sugino,Keishi; Ebihara,Satoru; Homma,Sakae; Iyoda,Akira

doi:10.3892/mco.2018.1595

Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery

Authors:
- Takashi Makino
- Hajime Otsuka
- Yoshinobu Hata
- Satoshi Koezuka
- Yoko Azuma
- Kazutoshi Isobe
- Keishi Sugino
- Satoru Ebihara
- Sakae Homma
- Akira Iyoda
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Affiliations: Division of Chest Surgery, Toho University School of Medicine, Ota, Tokyo 143‑8541, Japan, Division of Respiratory Medicine, Toho University School of Medicine, Ota, Tokyo 143‑8541, Japan, Department of Rehabilitation Medicine, Toho University School of Medicine, Ota, Tokyo 143‑8541, Japan
Published online on: March 26, 2018 https://doi.org/10.3892/mco.2018.1595
Pages: 647-652

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Abstract

Bronchodilators are essential for the perioperative management of patients with chronic obstructive pulmonary disease (COPD) undergoing surgery for lung cancer. The objective of the present study was to examine whether the usage of a long‑acting β2‑agonist (LABA) with a long‑acting muscarinic antagonist (LAMA) could optimize preoperative lung function and reduce the risk for postoperative pulmonary complications. Thirty‑two consecutive patients with moderate‑to‑severe COPD who underwent a lobectomy for lung cancer and received preoperative LAMA (n=19) or LAMA/LABA (n=13) therapy between January 2005 and December 2015 were enrolled in this retrospective study. The improvement of preoperative pulmonary function and the postoperative morbidity were compared between the patients with preoperative LAMA, and LAMA/LABA therapy. Increases in the forced expiratory volume in one second (FEV1) were significantly larger in the LAMA/LABA group than in the LAMA group (0.26±0.05 l vs. 0.07±0.05 l; P=0.0145). More patients in the LAMA/LABA group than in the LAMA group showed a marked improvement of >10% in %FEV1 after bronchodilators (85 vs. 32%; P=0.0046). The incidence of postoperative pneumonia was significantly lower in the LAMA/LABA group than in the LAMA group (0 vs. 26%; P=0.044). In conclusion, the present study showed that preoperative LAMA/LABA therapy was associated with larger improvements in preoperative pulmonary function and less postoperative pneumonia than LAMA therapy. These results may lead to greater improvements in FEV1 and less postoperative pneumonia by encouraging preoperative LAMA/LABA therapy in this patient population.

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