Favorable response to pemetrexed, cisplatin and bevacizumab in invasive mucinous adenocarcinoma: A case report and literature review

  • Authors:
    • Xian Wen Sun
    • Yong Jie Ding
    • Yu Yan Zhang
    • Pei Li Chen
    • Ya Ru Yan
    • Ji Min Shen
    • Qing Yun Li
  • View Affiliations

  • Published online on: June 11, 2018     https://doi.org/10.3892/mco.2018.1651
  • Pages: 192-196
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Abstract

Invasive mucinous adenocarcinoma (IMA) was formerly referred to as mucinous bronchioloalveolar carcinoma. The lack of effective chemotherapy and comprehensive treatment for this type of tumor poses a great challenge in clinical practice. We herein report the case of a male patient with IMA who was treated with a combination of pemetrexed (500 mg/m2), cisplatin (75 mg/m2) and bevacizumab (15 mg/kg) as first‑line chemotherapy. The patient achieved significant radiological improvement with 6 courses of this regimen. After the tumor progressed, the patient again achieved marked improvement with an additional 4 courses of the same regimen. The patient survived for a total of 30 months after the first chemotherapy. Therefore, bevacizumab in combination with pemetrexed/cisplatin may be an effective strategy for the treatment of IMA. The available literature on this chemotherapy regimen was also reviewed and discussed in the present study.
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August-2018
Volume 9 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Sun XW, Ding YJ, Zhang YY, Chen PL, Yan YR, Shen JM and Li QY: Favorable response to pemetrexed, cisplatin and bevacizumab in invasive mucinous adenocarcinoma: A case report and literature review. Mol Clin Oncol 9: 192-196, 2018.
APA
Sun, X.W., Ding, Y.J., Zhang, Y.Y., Chen, P.L., Yan, Y.R., Shen, J.M., & Li, Q.Y. (2018). Favorable response to pemetrexed, cisplatin and bevacizumab in invasive mucinous adenocarcinoma: A case report and literature review. Molecular and Clinical Oncology, 9, 192-196. https://doi.org/10.3892/mco.2018.1651
MLA
Sun, X. W., Ding, Y. J., Zhang, Y. Y., Chen, P. L., Yan, Y. R., Shen, J. M., Li, Q. Y."Favorable response to pemetrexed, cisplatin and bevacizumab in invasive mucinous adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 9.2 (2018): 192-196.
Chicago
Sun, X. W., Ding, Y. J., Zhang, Y. Y., Chen, P. L., Yan, Y. R., Shen, J. M., Li, Q. Y."Favorable response to pemetrexed, cisplatin and bevacizumab in invasive mucinous adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 9, no. 2 (2018): 192-196. https://doi.org/10.3892/mco.2018.1651