Open Access

Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report

  • Authors:
    • Bing Yan
    • Meiqi Cui
    • Junhao You
    • Fang Li
    • Hui Liu
  • View Affiliations

  • Published online on: October 5, 2018     https://doi.org/10.3892/mco.2018.1740
  • Pages: 607-612
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric adenocarcinoma concurrent with metastatic neuroendocrine cancer (NEC) is rare. In the present case report, a 39‑year‑old male was first pathologically diagnosed by gastric endoscopy as having a highly differentiated adenocarcinoma. Next, positron emission tomography‑computed tomography examination and bone marrow biopsy confirmed extensive metastasis. Subsequently, the patient underwent 6 cycles of immunotherapy (nivolumab, 160 mg) and 5 cycles of chemotherapy based on the XELOX regimen (oxaliplatin + capecitabine). Following this, the patient received the final cycles of nivolumab and XELOX; however, the patient then succumbed. Further biopsy of the metastatic collarbone lymph nodes indicated NEC. Overall, the progression‑free survival was ~3.5 months, and overall survival (OS) was ~6 months. The case presented the possibility of concurrent gastric adenocarcinoma and NEC in the clinic. In addition, the efficacy of a combined regimen such as immunotherapy and chemotherapy for such disorders still requires further validation in the future.
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December-2018
Volume 9 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Yan B, Cui M, You J, Li F and Liu H: Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report. Mol Clin Oncol 9: 607-612, 2018.
APA
Yan, B., Cui, M., You, J., Li, F., & Liu, H. (2018). Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report. Molecular and Clinical Oncology, 9, 607-612. https://doi.org/10.3892/mco.2018.1740
MLA
Yan, B., Cui, M., You, J., Li, F., Liu, H."Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report". Molecular and Clinical Oncology 9.6 (2018): 607-612.
Chicago
Yan, B., Cui, M., You, J., Li, F., Liu, H."Gastric adenocarcinoma is concurrent with metastatic neuroendocrine cancer treated with nivolumab and chemotherapy: A case report". Molecular and Clinical Oncology 9, no. 6 (2018): 607-612. https://doi.org/10.3892/mco.2018.1740