Evaluation of the prognostic utility of the combination of platelet count with mean platelet volume as a prognostic indicator in head and neck cancer

Tham,Tristan; Leung,Edric; Olson,Caitlin; Wotman,Michael; Khaymovich,Julian; Coury,Josephine; Teegala,Sireesha; Costantino,Peter

doi:10.3892/mco.2019.1813

Evaluation of the prognostic utility of the combination of platelet count with mean platelet volume as a prognostic indicator in head and neck cancer

Authors:
- Tristan Tham
- Edric Leung
- Caitlin Olson
- Michael Wotman
- Julian Khaymovich
- Josephine Coury
- Sireesha Teegala
- Peter Costantino
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Affiliations: Department of Otolaryngology ‑ Head and Neck Surgery, Zucker School of Medicine at Hofstra/Northwell, New York Head & Neck Institute, New York, NY 10075, USA
Published online on: February 22, 2019 https://doi.org/10.3892/mco.2019.1813
Pages: 457-462

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Abstract

The combination of platelet count to mean platelet volume (COP‑MPV) has been recently reported as a prognostic indicator of oral cavity cancer and other cancer sites. The aim of the present study was to validate the utility of the COP‑MPV as a prognostic indicator in all head and neck cancer (HNC) sites. The clinicopathological characteristics of the COP‑MPV with HNC were also investigated. This is a retrospective cohort study that recruited consecutively treated patients at a tertiary level academic hospital. Clinicopathological characteristics were recorded, including the COP‑MPV scores. Survival was analyzed using Kaplan‑Meier analysis, as well as multivariate Cox Proportional Hazards regression. COP‑MPV was not associated with the survival outcome in univariate or multivariate analysis. In the multivariate model, tumor differentiation, tumor stage, nodal stage, surgical margins and hemoglobin were revealed to be significantly associated with survival. The results demonstrated that the COP‑MPV is not a suitable prognostic factor for HNC.

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