Pre‑treatment psoas major volume is a predictor of poor prognosis for patients with epithelial ovarian cancer

Matsubara,Yuko; Nakamura,Keiichiro; Matsuoka,Hirofumi; Ogawa,Chikako; Masuyama,Hisashi

doi:10.3892/mco.2019.1912

Pre‑treatment psoas major volume is a predictor of poor prognosis for patients with epithelial ovarian cancer

Authors:
- Yuko Matsubara
- Keiichiro Nakamura
- Hirofumi Matsuoka
- Chikako Ogawa
- Hisashi Masuyama
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Affiliations: Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan
Published online on: August 19, 2019 https://doi.org/10.3892/mco.2019.1912
Pages: 376-382

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Abstract

Low skeletal muscle mass (sarcopenia) is an important prognostic risk factor for the outcome of a variety of cancer types. The current study investigated whether skeletal muscle area (SMA), psoas area (PA) and psoas major volume (PV) are associated with progression‑free survival (PFS) and overall survival (OS) in patients with epithelial ovarian cancer (OC). A total of 92 OC patients were enrolled in the present study. Pre‑treatment with SMA and PA was assessed using computed tomography (CT) and PV was calculated using a three‑dimensional‑CT (3D‑CT). The clinical factors associated with sarcopenia and prognosis were retrospectively evaluated. For all patients, the median PFS and OS were 19 and 32 months, respectively. Patients exhibiting lower PV (<195.6 cm3) had significantly poorer PFS and OS compared with patients exhibiting higher PV (≥195.6 cm3; P=0.018 and P=0.006), while those with low SMA (<92.92 cm2) had significantly worse OS than patients with higher SMA (≥92.92 cm2; P=0.030). PV was also demonstrated to be superior to SMA and PA in prognosis prediction. PV by 3D‑CT can serve as an indicator of poor prognosis in patients with OC.

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