Three cases of hepatocellular carcinoma treated 4 times with proton beams

Murakami,Motohiro; Fukumitsu,Nobuyoshi; Okumura,Toshiyuki; Numajiri,Haruko; Murofushi,Keiko; Ohnishi,Kayoko; Mizumoto,Masashi; Ishikawa,Hitoshi; Tsuboi,Koji; Sakurai,Hideyuki

doi:10.3892/mco.2019.1950

Three cases of hepatocellular carcinoma treated 4 times with proton beams

Authors:
- Motohiro Murakami
- Nobuyoshi Fukumitsu
- Toshiyuki Okumura
- Haruko Numajiri
- Keiko Murofushi
- Kayoko Ohnishi
- Masashi Mizumoto
- Hitoshi Ishikawa
- Koji Tsuboi
- Hideyuki Sakurai
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Affiliations: Department of Radiation Oncology and Proton Medical Research Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305‑8576, Japan, Department of Radiation Oncology, Kobe Proton Center, Kobe. Hyōgo 650‑0047, Japan
Published online on: November 18, 2019 https://doi.org/10.3892/mco.2019.1950
Pages: 31-35
Copyright: © Murakami et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

HCC may recur following surgery or radiofrequency ablation. Proton beam therapy (PBT) is a type of radiotherapy that achieves excellent local control of HCC without severe toxicity. The present study reported the long‑term outcome of 3 HCC patients who each received 4 repeat courses of PBT. All patients had a hepatitis B or C viral infection. A total of 14 lesions were treated using a curative PBT protocol and irradiated liver volumes in each treatment were 7‑50% of the total liver volume. Liver function in all cases was considerably preserved until the last follow‑up and patient survival was 51‑107 months from the first PBT with no local recurrence observed in the 14 lesions. The presented cases indicated that repeated PBT is an effective treatment option for recurrent HCC due to reduced liver damage and superior local treatment compared with other treatment options such as transarterial chemoembolization.

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