Clinical and reproductive outcomes of fertility‑sparing surgery in stage I epithelial ovarian cancer

Watanabe,Takafumi; Soeda,Shu; Nishiyama,Hiroshi; Kiko,Yuichiroh; Tokunaga,Hideki; Shigeta,Shogo; Yaegashi,Nobuo; Yamada,Hidekazu; Ohta,Tsuyoshi; Nagase,Satoru; Shoji,Tadahiro; Kagabu,Masahiro; Baba,Tsukasa; Shimizu,Dai; Sato,Naoki; Terada,Yukihiro; Futagami,Masayuki; Yokoyama,Yoshihito; Fujimori,Keiya

doi:10.3892/mco.2019.1954

Clinical and reproductive outcomes of fertility‑sparing surgery in stage I epithelial ovarian cancer

Authors:
- Takafumi Watanabe
- Shu Soeda
- Hiroshi Nishiyama
- Yuichiroh Kiko
- Hideki Tokunaga
- Shogo Shigeta
- Nobuo Yaegashi
- Hidekazu Yamada
- Tsuyoshi Ohta
- Satoru Nagase
- Tadahiro Shoji
- Masahiro Kagabu
- Tsukasa Baba
- Dai Shimizu
- Naoki Sato
- Yukihiro Terada
- Masayuki Futagami
- Yoshihito Yokoyama
- Keiya Fujimori
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Affiliations: Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan, Department of Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan, Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980‑8574, Japan, Miyagi Cancer Center, Medeshima‑shiote, Natori, Miyagi 981‑1293, Japan, Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, Yamagata 990‑9585, Japan, Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Morioka, Iwate 020‑8505, Japan, Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita 010‑8543, Japan, Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Hirosaki, Aomori 036‑8563, Japan
Published online on: November 22, 2019 https://doi.org/10.3892/mco.2019.1954
Pages: 44-50
Copyright: © Watanabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the oncologic safety and reproductive outcome in patients with stage I epithelial ovarian cancer (EOC) treated with fertility‑sparing surgery (FSS). Women aged ≤40 years with stage I EOC who had undergone FSS between 2000 and 2010 were retrospectively reviewed. Survival was examined using the Kaplan‑Meier method and statistical significance was analyzed using the log‑rank test. A total of 29 EOC patients (stage IA, n=14; stage IC1 n=6; stage IC3, n=9) from seven participating institutions belonging to the Tohoku Gynecologic Cancer Unit were enrolled. After a median follow‑up duration of 60.6 months (range, 6‑135 months), five patients (17.2%) experienced tumor recurrence. The respective five‑year relapse‑free survival (RFS) and overall survival (OS) rates were 90.9 and 100% for stage IA/IC1, and 43.8 and 87.5% for stage IC3. Significant differences in RFS were observed between stage IA/IC1 and IC3 patients (P=0.026). However, there was no significant difference in OS between patients with 1A/1C1 and those with 1C3 (P=0.712). After FSS, seven pregnancies occurred in five patients, which resulted in the birth of six healthy children. The results of the present study conﬁrmed that FSS may be an acceptable treatment method for stage IA and IC1 EOC, exhibiting a favorable reproductive outcome. However, the safety of FSS for treating stage IC3 EOC is uncertain and warrants further investigation.

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