Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report

  • Authors:
    • Hirotaka Noda
    • Kazuyoshi Masuda
    • Masami Kanbara
    • Hiromi Maeda
    • Tadao K. Kobayashi
    • Chikao Yutani
  • View Affiliations

  • Published online on: April 10, 2020     https://doi.org/10.3892/mco.2020.2030
  • Pages: 592-596
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Abstract

Sporadic gastrin‑producing neuroendocrine tumors (NETs) of the duodenum present with either Zollinger‑Ellison syndrome or unspecific syndromes. Ki‑67 scoring in cytopathology is an alternative approach for establishing the gastrinoma grade. Although the majority of NETs, including gastrinomas, occur in the duodenum, most research regarding the Ki‑67 index is focused on tumors of pancreatic origin. To the best of our knowledge, there is no study on the Ki‑67 index for cytological analysis of duodenal gastrinoma. The current report presents two cases of a 56‑year‑old man and a 66‑year‑old woman with NET G1 and G2 gastrinoma, respectively, arising in the duodenal bulb. The present report focused on the differences in nuclear pleomorphism and Ki‑67 index between these two cases.
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June-2020
Volume 12 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Noda H, Masuda K, Kanbara M, Maeda H, Kobayashi TK and Yutani C: Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report. Mol Clin Oncol 12: 592-596, 2020.
APA
Noda, H., Masuda, K., Kanbara, M., Maeda, H., Kobayashi, T.K., & Yutani, C. (2020). Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report. Molecular and Clinical Oncology, 12, 592-596. https://doi.org/10.3892/mco.2020.2030
MLA
Noda, H., Masuda, K., Kanbara, M., Maeda, H., Kobayashi, T. K., Yutani, C."Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report". Molecular and Clinical Oncology 12.6 (2020): 592-596.
Chicago
Noda, H., Masuda, K., Kanbara, M., Maeda, H., Kobayashi, T. K., Yutani, C."Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report". Molecular and Clinical Oncology 12, no. 6 (2020): 592-596. https://doi.org/10.3892/mco.2020.2030