Open Access

Development of diffuse large B‑cell lymphoma after sofosbuvir‑ledipasvir treatment for chronic hepatitis C: A case report and literature review

  • Authors:
    • Hiroyasu Sakai
    • Takao Miwa
    • Yoshikazu Ikoma
    • Tatsunori Hanai
    • Nobuhiko  Nakamura
    • Kenji Imai
    • Junichi Kitagawa
    • Yohei Shirakami
    • Nobuhiro  Kanemura
    • Atsushi  Suetsugu
    • Koji Takai
    • Makoto Shiraki
    • Masahito Shimizu
  • View Affiliations

  • Published online on: June 16, 2020     https://doi.org/10.3892/mco.2020.2071
  • Article Number: 1
  • Copyright: © Sakai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recently, treatments for chronic hepatitis C virus (HCV) infection have significantly improved by the development of direct‑acting antiviral agents (DAAs) and almost all patients with HCV can complete antiviral treatment without apparent adverse events. Malignant lymphoma, particularly B‑cell non‑Hodgkin's lymphoma, is one of the extrahepatic manifestations associated with chronic HCV infection. The effectiveness of anti‑HCV therapy with DAAs for B‑cell non‑Hodgkin's lymphoma has been demonstrated in recent reports, whereas late‑onset B‑cell non‑Hodgkin's lymphoma after HCV eradication with DAAs has occasionally been reported. In the present study, a 77‑year‑old man with chronic hepatitis C and intermediate liver cancer risk received sofosbuvir‑ledipasvir treatment for 12 weeks. Two months following the end of antiviral therapy, he had achieved sustained virologic response for 8 weeks. However, the patient occasionally found swelling of the right cervical lymph nodes without any subjective symptoms. Lymph node biopsy revealed diffuse large B‑cell lymphoma and whole‑body 18F‑fluorodeoxyglucose (FDG) positron emission tomography with computed tomography showed increased FDG uptake in the right cervical, right submandibular, mediastinal and mesenteric lymph nodes. The patient received six courses of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and achieved complete response at 8 months after chemotherapy initiation. Thus, the development of lymphoid malignancies may arise, even after HCV eradication with DAAs. Therefore, clinicians should be aware of such risks during and after antiviral treatment with DAAs.
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September-2020
Volume 13 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Sakai H, Miwa T, Ikoma Y, Hanai T, Nakamura N, Imai K, Kitagawa J, Shirakami Y, Kanemura N, Suetsugu A, Suetsugu A, et al: Development of diffuse large B‑cell lymphoma after sofosbuvir‑ledipasvir treatment for chronic hepatitis C: A case report and literature review. Mol Clin Oncol 13: 1, 2020.
APA
Sakai, H., Miwa, T., Ikoma, Y., Hanai, T., Nakamura, N., Imai, K. ... Shimizu, M. (2020). Development of diffuse large B‑cell lymphoma after sofosbuvir‑ledipasvir treatment for chronic hepatitis C: A case report and literature review. Molecular and Clinical Oncology, 13, 1. https://doi.org/10.3892/mco.2020.2071
MLA
Sakai, H., Miwa, T., Ikoma, Y., Hanai, T., Nakamura, N., Imai, K., Kitagawa, J., Shirakami, Y., Kanemura, N., Suetsugu, A., Takai, K., Shiraki, M., Shimizu, M."Development of diffuse large B‑cell lymphoma after sofosbuvir‑ledipasvir treatment for chronic hepatitis C: A case report and literature review". Molecular and Clinical Oncology 13.3 (2020): 1.
Chicago
Sakai, H., Miwa, T., Ikoma, Y., Hanai, T., Nakamura, N., Imai, K., Kitagawa, J., Shirakami, Y., Kanemura, N., Suetsugu, A., Takai, K., Shiraki, M., Shimizu, M."Development of diffuse large B‑cell lymphoma after sofosbuvir‑ledipasvir treatment for chronic hepatitis C: A case report and literature review". Molecular and Clinical Oncology 13, no. 3 (2020): 1. https://doi.org/10.3892/mco.2020.2071