Diagnosis and treatment of a rare tumor‑bladder paraganglioma

Li,Hang; Xie,Jiaodi; Chen,Zebo; Yang,Shangqi; Lai,Yongqing

doi:10.3892/mco.2020.2110

Diagnosis and treatment of a rare tumor‑bladder paraganglioma

Authors:
- Hang Li
- Jiaodi Xie
- Zebo Chen
- Shangqi Yang
- Yongqing Lai
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Affiliations: Department of Urology, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU‑HKUST (Peking University, Hong Kong University of Science and Technology) Medical Center, Shenzhen, Guangdong 518036, P.R. China
Published online on: August 11, 2020 https://doi.org/10.3892/mco.2020.2110
Article Number: 40

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Abstract

Bladder paragangliomas are very rare tumors that are often misdiagnosed. The present study retrospectively analyzed the clinical data and follow‑up results of patients with bladder paraganglioma that were treated surgically in Peking University Shenzhen Hospital between 2012 and 2018, and reviewed the relevant literature. A total of 4 patients with bladder paraganglioma were treated surgically from 2012 to 2018. All patients were female with ages ranging from 28 to 54 years old (average, 47.25). A total of one patient exhibited micturition attacks and palpitations, and one other exhibited gross hematuria. A total of two patients exhibited while no obvious symptoms. One patient exhibited elevated plasma catecholamine, was well prepared with medicine and underwent partial cystectomy, and 3 patients were not successfully diagnosed with paraganglioma before surgery. These patients received transurethral resection and 2 had distinct blood pressure elevation during operation. After surgery, the patients were followed‑up for 5‑69 months, during which all had normal blood pressure and none experienced recurrence. Bladder paragangliomas exhibit a variety of clinical presentations, which can be nonspecific for the non‑functional ones, therefore may easily lead to misdiagnosis. Surgeons must fully consider the possibility of this disease when dealing with non‑epithelial bladder tumors. Surgical resection is an effective treatment. For cases successfully diagnosed before surgery, partial cystectomy should be a treatment priority.

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