An aggressive nodular fasciitis lesion protruding from the palm (USP6 gene fusion helps differentiate from sarcomas): A case report
- Authors:
- Chigusa Sawamura
- Tabu Gokita
- Ayataka Ishikawa
- Jun Manabe
- Hiroaki Kanda
View Affiliations
Affiliations: Department of Orthopaedic Surgery, Saitama Cancer Center, Saitama 362‑0806, Japan, Department of Pathology, Saitama Cancer Center, Saitama 362‑0806, Japan
- Published online on: November 18, 2020 https://doi.org/10.3892/mco.2020.2172
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Article Number:
10
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Abstract
Nodular fasciitis is a mesenchymal lesion, which has been viewed as a reactive process. The MYH9‑USP6 fusion gene was recently detected in nodular fasciitis, and nodular fasciitis is now considered to be a self‑limiting neoplastic process. Recently, a case of nodular fasciitis that recurred a number of times and metastasized to soft tissues was reported, and the features of aggressive cases of nodular fasciitis are currently under investigation. Here, a case of locally aggressive nodular fasciitis is presented, in which the lesion grew rapidly and caused ulnar nerve palsy. The lesion was locally controlled via marginal excision, and no metastasis was identified at 24 months post‑operation. Histologically, the lesion was consistent with nodular fasciitis, and the detection of the MYH9‑USP6 fusion gene supported the diagnosis. Although most nodular fasciitis lesions are benign, some may be locally aggressive or even metastasize. In the case outlined in the present study, marginal excision was sufficient to locally control the lesion.
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View References
|
1
|
Oliveira AM and Chou MM: USP6-induced
neoplasms: The biologic spectrum of aneurysmal bone cyst and
nodular fasciitis. Hum Pathol. 45:1–11. 2014.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Erickson-Johnson MR, Chou MM, Evers BR,
Roth CW, Seys AR, Jin L, Ye Y, Lau AW, Wang X and Oliveira AM:
Nodular fasciitis: A novel model of transient neoplasia induced by
MYH9-USP6 gene fusion. Lab Invest. 91:1427–1433. 2011.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Goldblum JR, Weiss SW and Folpe AL (eds):
Benign fibroblastic/myofibroblastic proliferations, including
superficial fibromatoses. In: Enzinger and Weiss's Soft Tissue
Tumors. 6th edition. Elsevier Health Sciences, Philadelphia,
pp188-255, 2013.
|
|
4
|
Guo R, Wang X, Chou MM, Asmann Y, Wenger
DE, Al-Ibraheemi A, Molavi DW, Aboulafia A, Jin L, Fritchie K, et
al: PPP6R3-USP6 amplification: Novel oncogenic mechanism in
malignant nodular fasciitis. Genes Chromosomes Cancer. 55:640–649.
2016.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Kanaya K, Iba K, Yamashita T, Wada T and
Hasegawa T: Intraneural nodular fasciitis in a child: A case report
and review of the literature. J Hand Surg Am. 41:e299–e302.
2016.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Sevilla JJ, Ares-Rodriguez O, Seijas R and
Perez-Dominguez M: Unusual presentation of nodular fasciitis of the
hand. A case report. Acta Orthop Belg. 75:141–144. 2009.PubMed/NCBI
|
|
7
|
Al-Qattan MM and Arafah MM: Nodular
fasciitis of the hand: Excision preserving ‘vital’ structures. J
Hand Surg Eur Vol. 39:881–884. 2014.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Nishida Y, Tsukushi S, Wasa J, Iwata Y,
Kozawa E and Ishiguro N: Nodular fasciitis of the finger and hand:
Case report. J Hand Surg Am. 35:1184–1186. 2010.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Shin C, Low I, Ng D, Oei P, Miles C and
Symmans P: USP6 gene rearrangement in nodular fasciitis and
histological mimics. Histopathology. 69:784–791. 2016.PubMed/NCBI View Article : Google Scholar
|
