Open Access

Regorafenib‑induced exacerbation of chronic immune thrombocytopenic purpura in remission: A case report

  • Authors:
    • Shiro Kimbara
    • Yoshinori Imamura
    • Kimikazu Yakushijin
    • Ako Higashime
    • Taiji Koyama
    • Yoshimi Fujishima
    • Yohei Funakoshi
    • Masanori Toyoda
    • Naomi Kiyota
    • Hiroshi Matsuoka
    • Hironobu Minami
  • View Affiliations

  • Published online on: December 16, 2020     https://doi.org/10.3892/mco.2020.2192
  • Article Number: 30
  • Copyright: © Kimbara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Regorafenib is an oral multi‑kinase inhibitor which targets tumor angiogenesis, the tumor microenvironment and oncogenesis. Based on this mode of action, regorafenib has a broad spectrum of toxicities. However, at present, few reports have focused on autoimmune adverse events. We report a first case of regorafenib‑induced exacerbation of chronic immune thrombocytopenic purpura in remission during treatment for the patients with heavily treated advanced colorectal cancer. This case report highlights the need for caution with regard to regorafenib treatment in patients with cancer with concomitant immune thrombocytopenic purpura.
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February-2021
Volume 14 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Kimbara S, Imamura Y, Yakushijin K, Higashime A, Koyama T, Fujishima Y, Funakoshi Y, Toyoda M, Kiyota N, Matsuoka H, Matsuoka H, et al: Regorafenib‑induced exacerbation of chronic immune thrombocytopenic purpura in remission: A case report. Mol Clin Oncol 14: 30, 2021.
APA
Kimbara, S., Imamura, Y., Yakushijin, K., Higashime, A., Koyama, T., Fujishima, Y. ... Minami, H. (2021). Regorafenib‑induced exacerbation of chronic immune thrombocytopenic purpura in remission: A case report. Molecular and Clinical Oncology, 14, 30. https://doi.org/10.3892/mco.2020.2192
MLA
Kimbara, S., Imamura, Y., Yakushijin, K., Higashime, A., Koyama, T., Fujishima, Y., Funakoshi, Y., Toyoda, M., Kiyota, N., Matsuoka, H., Minami, H."Regorafenib‑induced exacerbation of chronic immune thrombocytopenic purpura in remission: A case report". Molecular and Clinical Oncology 14.2 (2021): 30.
Chicago
Kimbara, S., Imamura, Y., Yakushijin, K., Higashime, A., Koyama, T., Fujishima, Y., Funakoshi, Y., Toyoda, M., Kiyota, N., Matsuoka, H., Minami, H."Regorafenib‑induced exacerbation of chronic immune thrombocytopenic purpura in remission: A case report". Molecular and Clinical Oncology 14, no. 2 (2021): 30. https://doi.org/10.3892/mco.2020.2192