Multicentric glioblastoma in a 4‑year‑old female patient: A case report

Enomoto,Toshiyuki; Aoki,Mikiko; Kouzaki,Takamichi; Takahara,Masaki; Abe,Hiroshi; Nomura,Yuko; Hirose,Shinichi; Inoue,Tooru; Nabeshima,Kazuki

doi:10.3892/mco.2021.2252

Multicentric glioblastoma in a 4‑year‑old female patient: A case report

Authors:
- Toshiyuki Enomoto
- Mikiko Aoki
- Takamichi Kouzaki
- Masaki Takahara
- Hiroshi Abe
- Yuko Nomura
- Shinichi Hirose
- Tooru Inoue
- Kazuki Nabeshima
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Affiliations: Department of Pathology, Fukuoka University School of Medicine, Fukuoka 814‑0180, Japan, Department of Neurosurgery, Fukuoka University School of Medicine, Fukuoka 814‑0180, Japan, Department of Pediatrics, Fukuoka University School of Medicine, Fukuoka 814‑0180, Japan
Published online on: March 5, 2021 https://doi.org/10.3892/mco.2021.2252
Article Number: 90

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Abstract

In the USA and Germany, pediatric glioblastoma (pGBM) makes up <3% of childhood brain tumors. Occasionally, GBM has multiple contrast lesions and is referred to as multicentric GBM. The current study present a case of a four‑year‑old female patient presented with headache, vomiting and consciousness disturbance. Radiologically, a neoplastic lesion of the right frontal lobe with hemorrhage, and bilateral thalamus, right temporal and left occipital neoplastic lesions were identified. The right frontal lesion was not continuous to other lesions. It was concluded that the tumor was a multicentric GBM with intra‑tumoral hemorrhage. The tumor was pathologically GBM. Following surgery, the patient underwent chemotherapy and radiotherapy, but 11 months after surgery, the patient passed away. This case had features of childhood GBM and multicentric GBM and was difficult to treat.

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