Open Access

Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long‑term remission

  • Authors:
    • Toshiki Terao
    • Junichiro Yuda
    • Nobuhiko Yamauchi
    • Yong-Mei Guo
    • Kaoru Shimada
    • Masato Sugano
    • Genichiro Ishii
    • Yosuke Minami
  • View Affiliations

  • Published online on: April 23, 2021     https://doi.org/10.3892/mco.2021.2287
  • Article Number: 125
  • Copyright: © Terao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gray zone lymphoma (GZL) is a rare type of B‑cell lymphoma characterized by features of both diffuse large B‑cell lymphoma and classical Hodgkin lymphoma (cHL). The prognosis of GZL is poorer than that of cHL and mediastinal large B‑cell lymphoma. However, an optimal treatment strategy for relapsed/refractory (R/R) GZL has not been established in the clinical setting. The current study reported an excellent clinical response in a patient with R/R CD30‑positive GZL who received brentuximab vedotin (BV) maintenance after autologous stem cell transplantation (ASCT). Although the patient was resistant to prior treatments, BV maintenance after ASCT achieved long‑term remission. Hence, BV was determined to be a safe and effective therapeutic option for CD30‑positive R/R GZL.
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June-2021
Volume 14 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Terao T, Yuda J, Yamauchi N, Guo Y, Shimada K, Sugano M, Ishii G and Minami Y: Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long‑term remission. Mol Clin Oncol 14: 125, 2021
APA
Terao, T., Yuda, J., Yamauchi, N., Guo, Y., Shimada, K., Sugano, M. ... Minami, Y. (2021). Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long‑term remission. Molecular and Clinical Oncology, 14, 125. https://doi.org/10.3892/mco.2021.2287
MLA
Terao, T., Yuda, J., Yamauchi, N., Guo, Y., Shimada, K., Sugano, M., Ishii, G., Minami, Y."Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long‑term remission". Molecular and Clinical Oncology 14.6 (2021): 125.
Chicago
Terao, T., Yuda, J., Yamauchi, N., Guo, Y., Shimada, K., Sugano, M., Ishii, G., Minami, Y."Brentuximab vedotin maintenance after autologous stem cell transplantation for refractory gray zone lymphoma with long‑term remission". Molecular and Clinical Oncology 14, no. 6 (2021): 125. https://doi.org/10.3892/mco.2021.2287