Cerebellar preference of luminal A and B type and basal ganglial preference of HER2‑positive type breast cancer‑derived brain metastases

Izutsu,Nobuyuki; Kinoshita,Manabu; Ozaki,Tomohiko; Sakai,Mio; Nakanishi,Katsuyuki; Nakayama,Takahiro; Tamaki,Yasuhiro; Kishima,Haruhiko

doi:10.3892/mco.2021.2337

Cerebellar preference of luminal A and B type and basal ganglial preference of HER2‑positive type breast cancer‑derived brain metastases

Authors:
- Nobuyuki Izutsu
- Manabu Kinoshita
- Tomohiko Ozaki
- Mio Sakai
- Katsuyuki Nakanishi
- Takahiro Nakayama
- Yasuhiro Tamaki
- Haruhiko Kishima
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Affiliations: Department of Neurosurgery, Osaka International Cancer Institute, Osaka 541‑8567, Japan, Department of Neurosurgery, Kawachi General Hospital, Higashiosaka, Osaka 578‑0954, Japan, Department of Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka 541‑8567, Japan, Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka 541‑8567, Japan, Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan
Published online on: June 30, 2021 https://doi.org/10.3892/mco.2021.2337
Article Number: 175
Copyright : © Izutsu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The purpose of the current study was to investigate the hypothesis that the spatial distribution of brain metastases could be affected by the biological subtypes of breast cancer. CT (n=1) or MRI (n=66) images of 67 patients with a total of 437 treatment‑naive brain metastases from breast cancer were retrospectively reviewed. Patients were grouped according to the biological subtype of the tumor [luminal A, 28; luminal B, 9; human epidermal growth factor receptor 2 (HER2) positive, 14; triple‑negative breast cancer (TNBC), 16]. All images were standardized to the human brain MRI atlas provided by the Montreal Neurological Institute 152 database. The distribution pattern of brain metastases after image standardization was analyzed. The cerebellum and the frontal lobe were more commonly affected by breast cancer brain metastases. Brain metastases from luminal A and B types of breast cancer arose more often in the cerebellum. Brain metastases from HER2‑positive type breast cancer occurred more often in the putamen and the thalamus and less frequently in the cerebellum than other types (P=0.0057). The subtypes of breast cancer are related to differences in the spatial distributions of their brain metastases. These differences may be utilized to plan different cranial irradiation strategies according to the breast cancer subtypes.

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